Can Reatine Kinase-MB Be Greater Than Total Creatine Kinase? A case report

Immunoinhibition method, one of the most comınonly used ınethods to measure creatine kinaseMB (CK-MB) activity in elinical laboratories for the diagnosis of acute ınyocardial infarction, is not specific to the CK-MB isoenzyme. Some malignant and benign conditions nıay lead inferferences with this method. In this case report, we presented a patient with small-cell lung1cancer in when CK-MB activity has been found greater than total CK activity. It has been accepted that high CK-MB activity ıneasured by the method mentioned may deınonstrate false elevations which are actually due to CK-BB elevation. In conclusion, when acute ınyocardial infaretion is suspected, CK-MB activity ıneasured by inıınunoinhibition, especially in coexisting diseases that might increase CK-BB, may be misleading so methods specific to CK-MB should be used.