Evaluation of demographic and clinical characteristics of female patients presenting with MINOCA and differences between male patients: A subgroup analysis of MINOCA-TR registry [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2022; 50(1): 4-13 | DOI: 10.5543/tkda.2022.86219

Evaluation of demographic and clinical characteristics of female patients presenting with MINOCA and differences between male patients: A subgroup analysis of MINOCA-TR registry

Gülay Gök1, Ali Çoner3, Tufan Çınar2, Salih Kılıç4, Mustafa Yenerçağ5, Ahmet Öz6, Cenk Ekmekçi7, Özlem Özlük8, Mehdi Zoghi9, Asım Oktay Ergene10, Uğur Önsel Türk11
1Department of Cardiology, Medipol University Hospital, Istanbul, Turkey
2Department of Cardiology, Haydarpasa Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
3Department of Cardiology, Başkent University Alanya Application and Research Center; Antalya, Turkey
4Department of Cardiology, Health Sciences University, Adana Training and Research Hospital, Adana, Turkey
5Department of Cardiology, University of Health Sciences Samsun Training and Research Hospital, Samsun, Turkey
6Department of Cardiology, Istanbul Training and Research Hospital, Istanbul, Turkey
7Departmant of Cardiology, Tepecik Training and Research Hospital, İzmir, Turkey
8Department of Cardiology, Bursa İhtisas Training and Research Hospital, Bursa, Turkey
9Department of Cardiology, Ege University School of Medicine Hospital, İzmir, Turkey
10Department of Cardiology, Dokuz Eylul University Hospital, İzmir, Turkey
11Department of Cardiology, Economy University, İzmir, Turkey

AIM
Although the MINOCA (Myocardial Infarction with Non-obstructive Coronary Arteries) prevalence is higher in rate in female patients than male counterparts in previous cohorts, potential demographic and clinical differences between in female patients who are diagnosed as MINOCA vs MIOCA (Myocardial Infarction with obstructive Coronary Arteries) have not been studied until to date. The present study aimed to document these characteristics and to compare them between female MINOCA and MIOCA patients.

METHODS
The study was a subgroup analysis of the MINOCA-TR study. The study was a multi-center, observational cohort study that was conducted in Turkey between March 2018 and October 2018. In this study, 477 (29.3%) female patients who have been diagnosed with acute myocardial infarction were evaluated.

RESULTS
Among those women 49 (10.3%) of them were diagnosed as MINOCA (mean age: 58.9±12.9) and 428 (89.7%) of them had a final diagnosis of MIOCA (mean age: 67.4±11.8). The prevalences of hypertension, hyperlipidemia, and diabetes mellitus were significantly lower in the MINOCA group than in the MIOCA group. Additionally, the MINOCA group had higher rates of recent flu history and non-ST elevation myocardial infarction (NSTEMI) presentation compared with the MIOCA group. There were significant clinical differences in MINOCA patients in terms of gender. When compared to male cases, female patients were older, had higher systolic blood pressure and lower hemoglobin levels.

CONCLUSION
The study revealed that traditional coronary artery disease risk factors were in lower prevalence in female MINOCA patients compared to female patients who had final diagnosis of MIOCA.

Keywords: Female sex, MINOCA, demographics, risk factor

How to cite this article
Gülay Gök, Ali Çoner, Tufan Çınar, Salih Kılıç, Mustafa Yenerçağ, Ahmet Öz, Cenk Ekmekçi, Özlem Özlük, Mehdi Zoghi, Asım Oktay Ergene, Uğur Önsel Türk. Evaluation of demographic and clinical characteristics of female patients presenting with MINOCA and differences between male patients: A subgroup analysis of MINOCA-TR registry. Turk Kardiyol Dern Ars. 2022; 50(1): 4-13

Corresponding Author: Gülay Gök, Türkiye
Manuscript Language: Turkish
© Copyright 2022 Archives of the Turkish Society of Cardiology
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