Turk Kardiyol Dern Ars. 2013; 41(3): 185-190 | DOI: 10.5543/tkda.2013.83030

Relation of neutrophil/lymphocyte ratio with the presence and severity of coronary artery ectasia

S. Selim Ayhan¹, Serkan Öztürk¹, Alim Erdem¹, Mehmet Fatih Özlü¹, Mehmet Özyaşar¹, Kemalettin Erdem², Mehmet Yazıcı^1
1Department Of Cardiology, Abant Izzet Baysal University Faculty Of Medicine, Bolu, Turkey
²Department of Cardiovascular Surgery, Abant Izzet Baysal University Faculty Of Medicine, Bolu, Turkey

OBJECTIVES
It has been shown that the neutrophil to lymphocyte ratio (N/L ratio) is associated with cardiovascular events and mortality. In this study, we investigated the N/L ratio in patients with coronary artery ectasia (CAE).

STUDY DESIGN
Fifty patients diagnosed with CAE using coronary angiography were included in the study (29 male, 21 female; mean age, 51.1±7.1 years). The control group consisted of 28 patients who had normal coronary arteries as determined by coronary angiography (16 male, 12 female; mean age, 49.5±9.4 years). Basal characteristics were recorded. The number of ectatic segments was noted. Hematologic parameters were measured and the N/L ratio was calculated.

RESULTS
The N/L ratio was significantly higher in the CAE group compared with control group (median [25-75% percentile] 2.2 [1.6-3.0] vs. 1.8 [1.4-2.0], p=0.014, respectively). The Spearman correlation analysis demonstrated that the N/L ratio
positively correlated with number of ectatic segments (r=0.35; p<0.002). Multivariable logistic regression analysis showed an independent relationship between CAE and the N/L ratio (odds ratio 2.674, 95% confidence interval 1.184-6.039, p=0.018).

CONCLUSION
The N/L ratio is higher in patients with CAE. This ratio is related to presence and severity of CAE.

Keywords: Dilatation, pathologic/etiology, coronary aneurysm; coronary angiography; coronary vessels/pathology; lymphocyte count; neutrophils; risk assessment.

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