Distribution of Coronary Artery Lesions in Chronic Mitral Valve Regurgitation Due to Ischemic Papillary Muscle Dysfunction

Patients with coronary artery disease who had mitral regurgitation due to ischemic papillary muscle dysfunction were retrospectively evaluated in this study and a relation was sought between the distribution of coronary artery lesions and mitral regurgitation. Cases with other probable causes of mitral regurgitation were excluded. Among 4839 patients with coronary artery disease (stenosis of 50 % or more), 65 had both coronary disease and mitral regurgitation. The control group comprised the remaining 4774 patients who had coronary artery disease but no mitral regurgitation. In both groups the distribution of coronary artery lesions were examined. Mitral regurgitation consequent to papillary muscle dysfunction was not infrequently observed in single or multiple-vessel disease or in any combination of vessel involvement. However, triple-vessel disease tended to be more commonly associated (p> 0.05) and in cases with both right coronary artery and left circumflex artery lesions, the incidence of mitral regurgitation was significantly higher than in cases with single or triple vessel disease or another combination of two vessel disease (p< 0.05).