Adverse Plasma Apolipoprotein AI and B Levels in Adults of Istanbul, Turkey

During the Turkish Risk Factor Survey plasma concentrations of apolipoprotein AI (apoAI) and apo B were included in the monitoring of coronary risk assessment in a cohort of the İstanbul adult population representatively sampled. In 338 adults aged 27 years or over (mean age 48±12) comprising 160 men and 178 women plasma apolipoprotein AI and apo B values were determined by utilizing radial immunodiffusion plates (Behring) containing antisera of immunized sheep, and the remaining lipid and lipoprotein fractions by enzyınatic technique utilizing a Retlotran apparatus. Obtained findings were evaluated after stratification for sex and age groups. Mean values in the population sample for apoAI were 13% tower in men than in women (127±33 and 145.5±38 mg/di, respectively). By contrast, mean levels of apoBin women (129±46 mg/di) were as high as in men (127±40 mg/di). These implied slightly low levels of apoAI and conspicuously high levels of apoB in both genders. A mild (by 13%) and persistent rise of mean apoAI concentrations was displayed in both genders between the age groups 30-39 and 60-69 years. A rise of similar magnitude was noted across the same age groups in the mean apoB levels in men, whereas in women the escalation reached 37%. Mean apoB values closely paraHel ed levels of LDL-cholesterol in both sex es at middle-age (30-59 years) but started to fall in women one decade later than the latter. It was concluded in this study (which analyzed for the first time levels of apoAI and apoB in Turkish adults after stratifying for sex and age) that adult inhabitants of the megalopolis İstanbul exhibited an ad verse constellation of plasma apolipoproteins.