Turk Kardiyol Dern Ars. 2019; 47(7): 594-598 | DOI: 10.5543/tkda.2019.80027
The impact of the new World Symposium on Pulmonary Hypertension definition of pulmonary hypertension on the prevalence of pre-capillary pulmonary hypertension
Ümit Yaşar Sinan
, Özge Çetinarslan
, Alev Arat Özkan
, Murat Kazım Ersanlı
, Mehmet Serdar Küçükoğlu
Department of Cardiology, Istanbul University Cerrahpaşa Institute of Cardiology, Istanbul, Turkey
OBJECTIVE Since the first World Symposium on Pulmonary Hypertension (WSPH; Geneva, 1973), pulmonary hypertension (PH) has been defined as a mean pulmonary artery pressure (mPAP) ≥25 mm Hg measured at right heart catheterization (RHC) while at rest in the supine position. At the 6th WSPH congress (Nice, 2018), a new proposal was presented defining pre-capillary PH as mPAP >20 mm Hg, with pulmonary arterial wedge pressure (PAWP) <15 mm Hg, and pulmonary vascular resistance (PVR) >3 WU. The aim of this study was to investigate the impact of the new definition of PH on the number of pre-capillary PH patients.
METHODS The results of RHC performed with various clinical indications between 2017 and 2018 were analyzed. The 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) and the 6th WSPH congress PH definitions were used to identify PH patients.
RESULTS Fifty-eight RHC procedures were performed in our hospital in a 1-year period. Most were performed with a suspicion of PH (n=52). The remainder (n=6) were performed with indications of valvular heart disease or left heart disease. There were 40 females (69%) and 18 males (31%). The mean age was 53.3±16.6 years. The RHC results revealed a mean PAP of 36.4±16.4 mm Hg, PAWP of 12.6±3.9 mm Hg, and PVR of 4.9±4.4 WU. Forty-three of 58 patients (74.1%) were classified as pre-capillary PH according to the ESC/ERS PH guideline, whereas 50 of 58 patients (86.2%) had pre-capillary PH according to the new WSPH definition.
CONCLUSION The results of this study indicated that the impact of the new definition of PH on the number of pre-capillary PH patients identified was greater than the predicted <10%.
Hemodynamic, pre-capillary pulmonary hypertension; right heart catheterization; World Symposium on Pulmonary Hypertension.
How to cite this article
Ümit Yaşar Sinan, Özge Çetinarslan, Alev Arat Özkan, Murat Kazım Ersanlı, Mehmet Serdar Küçükoğlu. The impact of the new World Symposium on Pulmonary Hypertension definition of pulmonary hypertension on the prevalence of pre-capillary pulmonary hypertension. Turk Kardiyol Dern Ars. 2019; 47(7): 594-598
Corresponding Author: Ümit Yaşar Sinan, Türkiye