Short-term mortality of patients with saddle pulmonary embolism: A single-center study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2019; 47(4): 273-280 | DOI: 10.5543/tkda.2019.77292

Short-term mortality of patients with saddle pulmonary embolism: A single-center study

Reza Hajizadeh1, Samad Ghaffari1, Hamid Rajebi2, Hadiseh Kavandi1, Elnaz Javanshir1, Golshan Fahimi3, Sahar Ghodratizadeh4
1Cardiovascular Research Center, Tabriz University of Medical science, Tabriz, Iran
2Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
3Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
4School of medicine, Urmia University of Medical Science, Urmia, Iran

Although hemodynamic instability has been identified as the most established mortality predictor in acute pulmonary embolism (PE), the debate is still open about the prognostic significance of saddle pulmonary embolism (SPE). This study determined the in-hospital mortality rate of SPE patients diagnosed via computed tomographic pulmonary angiography (CTPA) and compared these cases with non-SPE patients.

The presence of SPE observed on CTPA was used to classify 492 consecutive patients into SPE and non-SPE groups. Different features were compared between the 2 groups, and independent predictors of in-hospital mortality in acute PE were identified.

A total of 70 patients (14.2%) had SPE. In univariate analysis, the SPE group was seen to have a higher in-hospital mortality rate, as well as a lower oxygen saturation level and systolic and diastolic blood pressure in comparison with the non-SPE group (all p values <0.005). Multivariate analysis revealed that SPE was an independent predictor of in-hospital mortality in acute PE patients (Odds ratio: 9.21, 95% confidence interval: 3.40-24.89; p value <0.001).

The results of this study indicated that SPE had a statistically significant importance in predicting in-hospital mortality and adverse events in PE patients. These findings were not consistent with many prior studies.

Keywords: saddle pulmonary embolism, in-hospital mortality, prognosis, mortality.

How to cite this article
Reza Hajizadeh, Samad Ghaffari, Hamid Rajebi, Hadiseh Kavandi, Elnaz Javanshir, Golshan Fahimi, Sahar Ghodratizadeh. Short-term mortality of patients with saddle pulmonary embolism: A single-center study. Turk Kardiyol Dern Ars. 2019; 47(4): 273-280

Corresponding Author: Reza Hajizadeh, Iran
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