The Association of Syntax and Mehran Scores with Inflammation in Patients with Contrast-Induced Nephropathy Secondary to Acute Coronary Syndrome

OBJECTIVE
Contrast induced nephropathy (CIN) is the third most common cause of hospital-acquired acute renal failure. The increased use of contrast material in diagnostic and interventional cardiac catheterization procedures has made CIN a frequently encountered problem in clinical cardiology practice.The aim of our study is to understand the role of inflammatory biomarkers in patients developing CIN and to evaluate the relationship of inflammation with MEHRAN Score (MRS) and Syntax Score (SS).


METHOD
The study was conducted retrospectively and a total of 2161 patients who applied to the cardiology clinic with acute coronary syndrome [unstable angina (USAP), Non-ST-Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI)] were included in the study. In the study, patients were divided into three groups: USAP(n: 477), NSTEMI(n: 612) and STEMI (n: 604). The relationship between Pan-immune Inflammation Value (PIV) and MRS and SS was evaluated.

Result: In patients developing CIN, in the intergroup (USAP, NSTEMI and STEMI) evaluation; PIV (1925.24[794.93-8412.79] vs 2178[1016.06-3273.56] vs 2262.97[1076.97- 4384.98] respectively), MRS (6.74±1.91 vs. 7.43±3.99 vs.7.6±3.08, respectively), SS (33.57±21.32 vs. 35.36±9.97 vs. 36.19±11.57 respectively) values were higher in the STEMI group than in the other two groups. A correlation was detected between PIV and MRS and SS in all groups.


CONCLUSION
PIV was found to be high in patients who developed CIN after acute coronary syndrome. PIV also correlated with Mehran score and SS. PIV can thus be a successful biomarker in the follow-up of CIN in this group of patients, as it is cheap and easy to study.