ISSN 1016-5169 | E-ISSN 1308-4488
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Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2013; 41(7): 617-624 | DOI: 10.5543/tkda.2013.68625

Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio

Ayhan Erkol1, Selçuk Pala2, Vecih Oduncu3, Alev Kılıcgedik2, Filiz Kızılırmak4, Can Yücel Karabay2, Ahmet Güler2, Cevat Kırma2
1Department of Cardiology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey
2Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey
3Department of Cardiology Fatih Medikal Park Hospital, Istanbul
4Department of Cardiology, Medipol University Hospital, Istanbul


OBJECTIVES
Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20±3 months after acute MI.

STUDY DESIGN
58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated.

RESULTS
The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were significantly correlated with left ventricular ejection fraction (LVEF) (ρ=0.34, p=0.009), end diastolic volume index (EDVi) (ρ=-0.39, p=0.002) and end systolic volume index (ESVi) (ρ=-0.40, p=0.002).

CONCLUSION
Plasma MMP-8 levels were found to still be high in post-MI patients 20±3 months after the index event. The levels were significantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function.

Keywords: Cardiac volume, coronary disease, biological markers/ blood, electrocardiography; ejection fraction; heart ventricles; matrix metalloproteinase 8; myocardial infarction/blood/enzymology.

Corresponding Author: Ayhan Erkol, Türkiye
Manuscript Language: English
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