Case Reports Dramatic Decrease in Left Ventricular Mass with Octreotide Treatment in a Patient with Primary Hypertrophic Cardiomyopathy [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1995; 23(5): 384-387

Case Reports Dramatic Decrease in Left Ventricular Mass with Octreotide Treatment in a Patient with Primary Hypertrophic Cardiomyopathy

Ali İhsan GÜNAL1, Orhan EREN1, Y.Ahmet IŞIK1, Hüseyin C. ELMACI1, Y.Hüseyin ÇELİKER1, Ahmet YILDIRIM1, Şafak YÜKSEL1, Cemal LÜLECİ1

Growth factors were recently held responsible in the pathogenesis of primary hypertrophic cardiomyopathy (PHCM). It appeared that octreotide (OCT), a long-acting somatostatin analog could effectively inhibit growth factors. With this knowledge, OCT treatment was applied to a 34-year-old patient with HCM subcutaneously for four weeks; 50µg three times per day during the first week and 100µg twice per day the following three weeks. Patient's functional capacity was class III, there were P pulmonale (in lead II P wave 0.6 mV) and inverted T waves (inleads I, aVL, V5-6) on the ECG; left ventricular posterior wall thickness was 17 mm, interventricular septum thickness was 24 mm, left ventricular mass (LVM) was 342 g by echocardiography. At the end of four weeks' treatment the functional capacity rose to I, P wave amplitude declined to 0.3 mV and T wave was diphasic on the ECG and the thickness of the posterior wall and of the ventricular septum declined to 14 mm and 16 mm, respectively. LVM was 242 g on echocardiography. No side effect was observed during treatment. In conclusion, the dramatic improvement obtained with OCT treatment in a patient with PHCM seems promising.

Keywords: Primary hypertrophic cardiomyopathy, octreotide, echocardiography

How to cite this article
Ali İhsan GÜNAL, Orhan EREN, Y.Ahmet IŞIK, Hüseyin C. ELMACI, Y.Hüseyin ÇELİKER, Ahmet YILDIRIM, Şafak YÜKSEL, Cemal LÜLECİ. Case Reports Dramatic Decrease in Left Ventricular Mass with Octreotide Treatment in a Patient with Primary Hypertrophic Cardiomyopathy. Turk Kardiyol Dern Ars. 1995; 23(5): 384-387
Manuscript Language: Turkish
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