Can High Triglyceride–Glucose Index Predict Major Cardiovascular Events in Patients with Coronary Bifurcation Lesions Undergoing a Double-Stent Strategy?

Objective: Coronary artery bifurcation lesions (CBLs) represent a complex form of coronary artery disease (CAD) and are associated with an unfavorable long-term prognosis. The triglyceride–glucose index (TyGi) has been shown to provide valuable prognostic information regarding the risk of major cardiovascular events (MACEs) in patients with CAD. This study aimed to determine whether an elevated TyGi could predict MACEs, including target lesion revascularization (TLR), myocardial infarction (MI), and all-cause mortality, over a five-year follow-up period in patients with CBLs undergoing a double-stent strategy.
Method: This study included 552 patients who underwent a double-stent strategy between January 2010 and December 2020.
Results: Receiver operating characteristic analysis identified an optimal TyGi cut-off value of 9.2877. Patients were subsequently divided into a low-TyGi group (Group 1) and a high-TyGi group (Group 2). During the five-year follow-up period, the incidence of MACEs was recorded. Kaplan–Meier analysis demonstrated a higher incidence of MACEs in Group 2 than in Group 1 (P = 0.008). In multivariate Cox regression analysis (CRA), ejection fraction, presence of a complex bifurcation lesion, TyGi, and SYNTAX score (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) were predictors of MACEs (P < 0.05).
Conclusion: An elevated TyGi may serve as a useful predictor of MACEs in patients with bifurcation lesions undergoing a double-stent strategy.

Keywords: Coronary arteries, diabetes mellitus, percutaneous coronary intervention, triglycerides