Effect of Allopurinol on Myocardial Recovery During Reperfusion

A comparative study on isolated guinea pig hearts was carried out to determine the effect of allopurinolol-added reperfusion solution on myocardial recovery after global ischemia. After 20 minutes of normothermic ischemia two groups of solutions (1- Krebbs Solution 2- Krebsbs Solution + Allopurinol 1 mmol/L) were used for reperfusion (10 animals for each group). Postischemic myocardial functions (heart rate, ventricular contractility and heart work) and tissue enzymes (CK-MB, LDH) were compared with their preischemic values. Addition of allopurinol 1 mmol/L to reperfusion solution improved postischemic myocardial functions and decreased myocardial injury.