Alterations of Vascular Cell Adhesion Molecule, Interleukin, Fibrinogen Levels Following Interventional Revascularization Procedures and Relationship with Restenosis

Coronary artery injuries occurred during interventional revascularization procedures may lead to acute occlusion and restenosis. Cytokines and adhesion molecules are major elements for the adhesion of the cells to the vasecular endothelium and regulation w ith the vessel walls. The aim of this study is to determine the alterations in the levels of vascular adhesion molecule (VCAM-1), interleukin- 6 (IL-6), interleukin-2 receptor (IL-2R), fibrinogen and leukocytes following stent implantations. The study consists of 29 patients. Blood samples were taken before the proedure (BP), at the third hour of the procedure (AP-3), and 24th hour (AP-24). Restenosis was determined by coronary angiograph performed at the ı 16±5 days. In the ovarall patient population, we observed a significant increase in the VCAM - I levels at the 24th ho ur. (pKeywords: Adhesion molecule, interleukin, stent