Levels of C-Reactive Protein, Interleukin-6 and Activated T Lymphocyte in Patients with Unstable Angina Pectoris and Their Relation with Ischemia

This study aimed to evaluate and compare C-reactive protein (CRP), interleukin-6 (IL-6) and activated T lymphocyte (ATL) levels of 14 patients with unstable angina pectoris (UAP) of Class IIIB (13 male, mean age 62±8 years) within the first 24 h after chest pain (early period), within 3-5 daysafter the control of ischemic pain (in termediate period) and within 14-2 1 days fo llowing the revascularization procedure (Iate period). CRP levels were 3.53±2.83 mg/di, 2 .67±3.28 mg/di and 1.22±1.08 mg/di in the early, intermediate and Iate periods, respectively. The difference between the early and intermediate, the early and Iate, and the intermediate and Iate periods were s ignificant (p<0.04, p0.05). The re w as a good re lation between the CRP and IL-6 leve ls of intermediate period (r=0.73, p<0.001)). Ischemia was controlled with optimal medical therapy in 8 patients (Group I) whereas medical therapy failed in 6 patients (Group II) in whom interventionaJ treatment was preferred. CRP Ievels of Group I and Group II w ere 2.45± 1. 73 mg/d! and 4.98±3.49 mg/d! (p<0.05), respectively in the early period, whereas the levels were 0.90±0.65 mg/d! and 5.05±3.94 mg/d! (p<0.006) in the intermed iate period and finally O. 78±0.46 mg/di and 1.80( 1.43 mg/di (p<0.04) in the Iate period. There was significan t differences in IL-6 levels of Group I and Group II in both the early and intermediate periods (12.3 1±7.72 pg/ml vs 24.26±13.29 pg/ml, p<0.03; and 10.76±5.84 pg/ml vs 26.25±20.50 pg/ml, p=0.03, respectively). However, no signif icant difference w as fo und between groups in the Iate period. A TL levels were comparable between groupsin the early, intermediate and Iate periods. Asa conclusion, these data suggested that; CRP, IL-6 and A TL !eve! s in patients with UAP were increased and there was an association between the increase in CRP and IL-6 levels and the severity of ischemia.