Determination of the Influence of Left Ventricular Enddiastolic Pressure on Left Ventricular Filling Parameters by Pulsed Doppler Echocardiography in Patients with Coronary Artery Disease

The influence of left ventricular enddiastolic pressure (L VEDP) on left ventricular filling parameters was studied in two different patient groups with coronary artery disease. The fırst group comprised 12 male patients with LVEDP > 20 mmHg, the second group 20 male patients with LVEDP < 20 mmHg. Pulsed Doppler echocardiography was done to all patients within 24 hours of cardiac catheterisation and peak early filling velocity (E), peak Iate (atrial) filling velocity (A), ratio of E/A were determined. Additionally, the area under the early filling curve (A integral) and their ratios were measured. Comparison of the two groups failed to disclose any significant difference in left ventricular filling parameters {group I E/A: 0.87±0.1, group II E/A: 0.86±0.08, p>0.05). Thus it was shown that pulsed Doppler echocardiography could not provide any contribution to determine LVEDP, whether high or not. The results of this study indicate that left ventricular filling dynamics as assessed by Doppler-derived transmitral inflow velocities are not related to left ventricular filling pressures in patients with coronary artery disease.