Hematological incidies may predict oxidative stress in patients with ST-segment elevation myocardial infarction

OBJECTIVE
Oxidative stress is closely related to the development of atherosclerosis and acute coronary syndromes. In this study, we aimed to examine the relationship between hemogram incidies and oxidative stress parameters in patients with ST segment elevation myocardial infarction(STEMI).


METHODS
A single-centred, prospective and cross-sectional study was performed in 61 patients with STEMI. Before coronary angiography, in the blood samples taken from the peripheral vein hemogram incidies and oxidative stress parameters such as total oxidative status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were examined. We examined a total of fifteen hemogram indexes.


RESULTS
Most of the study patients were male (78%) and the mean age was 59.3 ± 12.2 years. Mean corpuscular volume (MCV) value was found to be negatively and moderately significantly correlated with TOS and OSI values (r = -0.438, r = -0.490, p <0.001). A negative and moderate significant correlation was found between mean corpuscular hemoglobin (MCH) and TOS and OSI values (r = -0.487, r = -0.433, p <0.001). Red cell distribution width (RDW) value was found to be positively and moderate correlated with TOS (r = 0.537, p <0.001). RDW was also found to be moderately and statistically significantly correlated with OSI value (r = 0.410, p = 0.001). In ROC analysis, MCV, MCH and RDW levels have been successful in predicting TOS and OSI.


CONCLUSION
We conclude that MCV, MCH and RDW levels predict oxidative stress in patients with ST-segment elevation myocardial infarction.