Anti-ischaemic and Anti-anginal Effects of Nisoldipine and Ramipril in Patients with Cardiological S)'ndrome X

We investigated anti-ischaemic and anti-anginal effects of nisoldipine and ramipril in patients with the cardiological syndrome X. After a two-week wash-out period, 1 8 patients (7 men, 1 ı women; m ean age: 46± ı O years) w ith cardiological syndrome X (stable angina pectoris, positive exercise test, negative ergonovine test, and normal coronary angiography) were given nisoldipine 5 mg twice daily for four weeks. And after a second twoweek wash-out period, the same patients were given ramipril 2.5 mg daily for four weeks. Treadınili exercise test with modified Bruce protocol was performed at the en d of each period. The time until anginal attack occurred (p=0.006 vs p=0.02), total exercise time (p=0.0008 vs p=0.02), and mean metabolic equivalent (p=O.OOı6 vs p=O.O 1) were increased significantly after nisoldipine and ramipril therapy periods. The time until ST segment depression by Imm occurred (p=0.002) was increased significantly after nisoldipine therapy. The time until ST segment de press i on recovery (p=O.O 16 vs p=O.O 1 2), the weekly number of angina pectoris (p=O.OO vs p=0.028), and the weekly number of sublingual nitroglycerin consumption (p=O.OO vs p=0.012) were decreased significantly after nisoldipine and ramipril therapy periods. We conclude that ıo mg/daily nisoldipine or 2.5 mg/daily has anti-ischaemic and anti-anginal effects in patients with cardiological syndrome X.