Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2022; 50(1): 34-45 | DOI: 10.5543/tkda.2022.21003

Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women

Filiz Güçlü Geyik1, Aycan Fahri Erkan2, Aybike Sena Özuynuk1, Berkay Ekici2, Neslihan Çoban1
1Department of Genetics, İstanbul University Aziz Sancar Institute of Experimental Medicine, İstanbul, Turkey
2Department of Cardiology, Ufuk University School of Medicine, Ankara, Turkey


OBJECTIVE
Intelectin-1 is an anti-inflammatory adipokine encoded by the Intelectin 1 (ITLN1) gene. Genetic variations in the ITLN1 gene affect the risk of coronary artery disease (CAD) and related CAD risk factors. In this study, we aimed to investigate whether the ITLN1 gene Val109Asp polymorphism has an effect on the severity of CAD and serum lipid levels in both men and women.

METHODS
A total of 493 subjects who underwent coronary angiography (43.5% women, mean age 63.1±9.5 years) were grouped as individuals with critical CAD (≥70% stenosis, n=202), non-critical CAD (31%-69% stenosis, n=90), and non-CAD (control group) (1%-30% stenosis, n=201). Genotyping was performed using LightSNiP assay in Real-Time PCR.

RESULTS
The frequency of the Val allele was significantly different among all the patients with critical CAD (n=41) and non-CAD control (n=51) groups in women (p=0.033) but not in men (n=77 and n=38). Women with the Val allele had a 1.69-fold increased risk for critical CAD (p=0.033). In addition, the presence of Val allele was associated with higher coronary stenosis after adjustment for several confounders
only in women with critical CAD (p=0.025). Furthermore, carriers of the Val allele exhibited an increased low-density lipoprotein cholesterol (LDL-C) in men with critical CAD than in those with non-CAD (p<0.05).

CONCLUSION
These results suggest that the Val allele of the ITLN1 Val109Asp polymorphism is associated with critical CAD and high LDL-C levels in our study population. Further studies are required to elucidate the effect of Val109Asp polymorphism on CAD pathogenesis.

Keywords: Intelectin-1, ITLN1 gene, coronary artery disease, Val109Asp

How to cite this article
Filiz Güçlü Geyik, Aycan Fahri Erkan, Aybike Sena Özuynuk, Berkay Ekici, Neslihan Çoban. Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. Turk Kardiyol Dern Ars. 2022; 50(1): 34-45

Corresponding Author: Filiz Güçlü Geyik, Türkiye
Manuscript Language: English
© Copyright 2022 Archives of the Turkish Society of Cardiology
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