Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2013; 41(1): 45-50 | DOI: 10.5543/tkda.2013.26235

Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease

Adnan Karan1, Yeşim Güray2, Ümit Güray2, Burcu Demirkan2, Ramazan Astan3, Erkan Baysal4, Ayşe Çolak2, Fatih Mehmet Uçar2, Ahmet İşleyen2, Selçuk Kanat2, Şule Korkmaz5
1Department Of Radiology, Turkiye Yuksek Ihtisas Education And Research Hospital, Ankara, Turkey
2Department Of Cardiology, Turkiye Yuksek Ihtisas Education And Research Hospital, Ankara, Turkey
3Tatvan Can Hospital, Bitlis, Turkey
4Department Of Cardiology, Diyarbakir Education And Research Hospital, Diyarbakir, Turkey
5Department Of Cardiology, Ufuk University, Faculty Of Medicine, Ankara, Turkey


OBJECTIVES
The aim of this study was to assess the relationship between mean platelet volume (MPV) and the presence and extent of coronary artery disease (CAD) in patients who underwent coronary angiography for stable chest pain.

STUDY DESIGN
A total of 540 patients (350 male, 190 female; mean age: 59.6±11.4 years) were consecutively included in the study. The patients were divided into four groups according to the presence and extent of their CAD as follows: Group 1 - patients with no significant CAD, group 2 - one vessel disease, group 3 - two vessel diseases, and group 4 - three vessel disease. Also, the Gensini score of each coronary angiogram was calculated.

RESULTS
There were 159 patients in group 1, 169 in group 2, 110 in group 3, and 102 in group 4. As expected, we found significant differences among the groups regarding mean age and other coronary risk factors including gender, hypertension, diabetes mellitus, hyperlipidemia, smoking, and family history of ischemic heart disease. However, there were no significant differences among the groups regarding platelet counts and MPV values (8.5±0.1 fl, 8.5±1.2 fl, 8.6±0.9 fl and 8.6±0.9 fl, MPV values of groups 1-4, respectively). Although the Gensini score was found to be significantly correlated with age, plasma uric acid level, white blood cell count, hemoglobin level, fasting blood glucose, and high density lipoprotein level, no significant association was detected between MPV and Gensini score values.

CONCLUSION
This study is one of the largest studies assessing the relationship between MPV and the extent of coronary atherosclerosis in patients with stable CAD to date. However, we found no association between MPV and the presence and extent of coronary atherosclerosis.

Keywords: Angina pectoris, atherosclerosis; coronary disease/ blood; myocardial infarction; blood platelets; platelet activation; platelet count.

How to cite this article
Adnan Karan, Yeşim Güray, Ümit Güray, Burcu Demirkan, Ramazan Astan, Erkan Baysal, Ayşe Çolak, Fatih Mehmet Uçar, Ahmet İşleyen, Selçuk Kanat, Şule Korkmaz. Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease. Turk Kardiyol Dern Ars. 2013; 41(1): 45-50

Corresponding Author: Adnan Karan, Türkiye
Manuscript Language: Turkish
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