Turk Kardiyol Dern Ars. 2013; 41(1): 45-50 | DOI: 10.5543/tkda.2013.26235

Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease

Adnan Karan¹, Yeşim Güray², Ümit Güray², Burcu Demirkan², Ramazan Astan³, Erkan Baysal⁴, Ayşe Çolak², Fatih Mehmet Uçar², Ahmet İşleyen², Selçuk Kanat², Şule Korkmaz^5
1Department Of Radiology, Turkiye Yuksek Ihtisas Education And Research Hospital, Ankara, Turkey
²Department Of Cardiology, Turkiye Yuksek Ihtisas Education And Research Hospital, Ankara, Turkey
³Tatvan Can Hospital, Bitlis, Turkey
⁴Department Of Cardiology, Diyarbakir Education And Research Hospital, Diyarbakir, Turkey
⁵Department Of Cardiology, Ufuk University, Faculty Of Medicine, Ankara, Turkey

OBJECTIVES
The aim of this study was to assess the relationship between mean platelet volume (MPV) and the presence and extent of coronary artery disease (CAD) in patients who underwent coronary angiography for stable chest pain.

STUDY DESIGN
A total of 540 patients (350 male, 190 female; mean age: 59.6±11.4 years) were consecutively included in the study. The patients were divided into four groups according to the presence and extent of their CAD as follows: Group 1 - patients with no significant CAD, group 2 - one vessel disease, group 3 - two vessel diseases, and group 4 - three vessel disease. Also, the Gensini score of each coronary angiogram was calculated.

RESULTS
There were 159 patients in group 1, 169 in group 2, 110 in group 3, and 102 in group 4. As expected, we found significant differences among the groups regarding mean age and other coronary risk factors including gender, hypertension, diabetes mellitus, hyperlipidemia, smoking, and family history of ischemic heart disease. However, there were no significant differences among the groups regarding platelet counts and MPV values (8.5±0.1 fl, 8.5±1.2 fl, 8.6±0.9 fl and 8.6±0.9 fl, MPV values of groups 1-4, respectively). Although the Gensini score was found to be significantly correlated with age, plasma uric acid level, white blood cell count, hemoglobin level, fasting blood glucose, and high density lipoprotein level, no significant association was detected between MPV and Gensini score values.

CONCLUSION
This study is one of the largest studies assessing the relationship between MPV and the extent of coronary atherosclerosis in patients with stable CAD to date. However, we found no association between MPV and the presence and extent of coronary atherosclerosis.

Keywords: Angina pectoris, atherosclerosis; coronary disease/ blood; myocardial infarction; blood platelets; platelet activation; platelet count.

---

CITE