Serum lactate level may predict the development of acute kidney injury in acute decompensated heart failure [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2020; 48(7): 683-689 | DOI: 10.5543/tkda.2020.25679

Serum lactate level may predict the development of acute kidney injury in acute decompensated heart failure

Muzaffer Kahyaoglu1, Ahmet Karaduman2, Çetin Geçmen2, Özkan Candan2, Ahmet Güner3, Ender Ozgün Cakmak2, Emrah Bayam4, Yusuf Yılmaz5, Mehmet Çelik2, Ibrahim Akin Izgi2, Cevat Kirma2
1Department of Cardiology, Gaziantep Abdülkadir Yüksel State Hospital, Gaziantep, Turkey
2Department of Cardiology, Kartal Koşuyolu Yüksek İhtisas Training and Research Hospital, İstanbul, Turkey
3Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbul, Turkey
4Department of Cardiology, Ümraniye Training and Research Hospital, İstanbul, Turkey
5Department of Cardiology, Amasya Merzifon State Hospital, Amasya, Turkey


OBJECTIVE
Acute decompensated heart failure (ADHF) is a life-threatening medical condition and more than 30% of patients hospitalized for ADHF develop acute kidney injury (AKI), which increases the rate of both mortality and morbidity. Previous research has indicated that several biomar-
kers may help to predict the development of AKI. The aim of this study was to investigate the relationship between lactate level at the time of admission and AKI in ADHF patients.

METHODS
A total of 154 consecutive ADHF patients were prospectively enrolled from June 2018 to December 2018, and after applying the exclusion criteria, a total of 91 patients were included in the study. The patients were divided into 2 groups: those with and without AKI.

RESULTS
There were 63 patients in the group without AKI and 28 patients in the group with AKI. The AKI group had a higher percentage of a history of chronic kidney disease (CKD), a higher creatinine level, lower glomerular filtration rate level, lower bicarbonate level, higher lactate level, and a lower left ventricular ejection fraction compared with the non-AKI group (p<0.05 for all parameters). Multiple logistic regression analysis determined that CKD history (odds ratio [OR]: 4.003, 95% confidence interval [CI]: 1.295–12.371; p=0.016) and lactate level (OR: 1.545, 95% CI: 1.222–1.954; p<0.001) were independent predictive parameters for developing AKI.

CONCLUSION
An elevated lactate level may help to make an early diagnosis of AKI, an important concern in ADHF.

Keywords: Acute decompensated heart failure, acute kidney injury; lactate.

How to cite this article
Muzaffer Kahyaoglu, Ahmet Karaduman, Çetin Geçmen, Özkan Candan, Ahmet Güner, Ender Ozgün Cakmak, Emrah Bayam, Yusuf Yılmaz, Mehmet Çelik, Ibrahim Akin Izgi, Cevat Kirma. Serum lactate level may predict the development of acute kidney injury in acute decompensated heart failure. Turk Kardiyol Dern Ars. 2020; 48(7): 683-689

Corresponding Author: Muzaffer Kahyaoglu, Türkiye
© Copyright 2020 Archives of the Turkish Society of Cardiology
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