Turk Kardiyol Dern Ars. 2002; 30(1): 36-40
Evaluation of Enalapril Losartan Treatment with Cardiopulmonary Exercise Test in Patients with Left Ventricular Systolic Dysfunction
, Şennur Ünal DAYİ1
, Haldun AKGÖZ1
, Ömer DAĞ1
, Seden Erten ÇELİK1
, İbrahim SARI1
, Gülşah TAYYARECİ1
, Tezer ULUSOY112345678
OBJECTIVE The aim of this study was to evaluate enalapril+losartan treatment with cardiopulmonary exercise test (CPET) in patients with left ventricular systolic dysfunction.
METHODS The patients with left ventricular systolic dysfunction (ejection fraction: ?40%) were included in this study. A totall of 30 subjects were studied; 20 patients (18 male, 2 female; mean age:62±6) as the study group and 10 patients (8 male, 2 female; mean age:59±11) as control group. All study patients were using enalapril 20 mg/day initially. Fifty mg losartan was added to the study group. CPET was performed to the study group before and 6-8 weeks after beginning of the losartan therapy. To the control group CPET was performed twice; at the begining and 6-8 weeks later without any change in the treatment protocol.
RESULTS In the study group the average exercise times were 361±192 sec. and 454±205 sec., before and after the study, respectively (p=0,001); peak VO2 values were 1209±366 ml/min. and 1284±398 ml/min.; anaerobic treshold VO2 values were 788±187 ml/min. and 855±217 ml/min before and after study respectively (p=0,01). Peak heart rates were 141±28 /min and 143±22 /min (p=0,35); peak VO2/HR values were 9,02±3,1 ml/min and 9,3±3,0 ml/min (p=0,4) before and after study, respectively. On the other hand, in the control group average exercise times were 556±250 sec 528±251 sec (p=0,8), peak VO2 values were 1502±537 ml/min and 1450±501 ml/min (p=0,2); and anaerobic treshold VO2 values were 1005±338 ml/min and 975±319 ml/min (p=0,7) before and after study, respectively. At the highest comparable exercise stage for both tests in the study group VE/VO2 ratio declined from 35,13±6,2 to 32,44±5,6 (p=0,07). VE values from 37,5±10,9 lt to 33,99±10,14 lt (p=0,02); and heart rate from 140±27/min to 132±21 /min (p=0,02). There was no statistical difference in these parameters in the control group.
CONCLUSION Addition of losartan to the standart therapy in patients with left ventricular systolic dysfunction; improves exercise capacity and causes lower heart rate and ventilation requirements for the same exercise stage.
How to cite this article
Tamer AKBULUT, Şennur Ünal DAYİ, Haldun AKGÖZ, Ömer DAĞ, Seden Erten ÇELİK, İbrahim SARI, Gülşah TAYYARECİ, Tezer ULUSOY. Evaluation of Enalapril Losartan Treatment with Cardiopulmonary Exercise Test in Patients with Left Ventricular Systolic Dysfunction. Turk Kardiyol Dern Ars. 2002; 30(1): 36-40