Association of polymorphisms in the sex hormone genes with the presence and severity of coronary artery disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2022; 50(1): 22-33 | DOI: 10.5543/tkda.2022.17203

Association of polymorphisms in the sex hormone genes with the presence and severity of coronary artery disease

Neslihan Çoban1, Aybike Sena Özuynuk1, Aycan Fahri Erkan2, Aysem Kaya3, Berkay Ekici2, Filiz Güçlü Geyik1, Evin Ademoğlu4, Günay Can5, Nihan Erginel Ünaltuna1
1Department of Genetics, Aziz Sancar Institute For Experimental Medicine, Istanbul University, Istanbul, Turkey
2Department of Cardiology, Ufuk University Medical Faculty, Ankara, Turkey
3Departments of Biochemistry Laboratory, Institute of Cardiology, Istanbul University-Cerrahpasa, Istanbul, Turkey
4Department of Biochemistry, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey
5Department of Public Health, Istanbul University-Cerrahpasa, Cerrahpaşa Medical Faculty, Istanbul, Turkey


OBJECTIVE
Coronary artery disease (CAD) is an important public health problem worldwide. Therefore, it is important to identify the molecular mechanisms and the candidate gene polymorphisms involved in the development of CAD. In this study, we focused on 2 polymorphisms of the atherosclerosis-related genes, ESR1 and CYP19A1.


METHODS
Unselected 339 individuals who underwent coronary angiography were divided into 2 groups: those with normal coronary arteries (≤30% stenosis) and those with critical disease (≥50% stenosis). Individuals were genotyped for CYP19A1 rs10046 C/T and ESR1 rs2175898 A/G polymorphisms using hybridization probes in real-time PCR. In addition, Gensini and SYNTAX scores were assessed.


RESULTS
ESR1 polymorphism was significantly associated with CAD in men (p=0.036) via G allele carriage. Multiple logistic regression analyses showed that ESR1 rare allele carriage was associated with CAD presence (Odds ratio=2.12, 95% confidence interval 1.01–4.1, p=0.025), adjusted for age, HDL-C, LDL-C and smoking status in the male group. CYP19A1 rs10046 T allele carriers had a 2.84-fold increased risk for complex CAD in multiple logistic regression analysis (p=0.016). Furthermore, the univariate analysis of variance
indicated that T allele carriage of rs10046 polymorphism was associated with increased SYNTAX and Gensini scores (p<0.05). Female patients who were ESR1 G allele carriers with CAD had higher adiponectin levels (p=0.005), whereas HbA1c levels were associated with T allele of CYP19A1 in the CAD group (p=0.004) and male CAD group (p=0.018).


CONCLUSION
The CYP19A1 and ESR1 polymorphisms were associated with the presence and severity of CAD. These gene polymorphisms warrant further studies for the elucidation of their contribution to CAD development.

Keywords: Coronary artery disease, CYP19A1, ESR1, polymorphism, Gensini Score, SYNTAX Score

How to cite this article
Neslihan Çoban, Aybike Sena Özuynuk, Aycan Fahri Erkan, Aysem Kaya, Berkay Ekici, Filiz Güçlü Geyik, Evin Ademoğlu, Günay Can, Nihan Erginel Ünaltuna. Association of polymorphisms in the sex hormone genes with the presence and severity of coronary artery disease. Turk Kardiyol Dern Ars. 2022; 50(1): 22-33

Corresponding Author: Neslihan Çoban, Türkiye
Manuscript Language: English
© Copyright 2022 Archives of the Turkish Society of Cardiology
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