Clinical implications and indicators of mortality among patients hospitalized with concurrent COVID-19 and myocardial infarction [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2021; 49(4): 293-302 | DOI: 10.5543/tkda.2021.14331

Clinical implications and indicators of mortality among patients hospitalized with concurrent COVID-19 and myocardial infarction

Hamed Tavolinejad, Kaveh Hosseini, Saeed Sadeghian, Hamidreza Pourhosseini, Masoumeh Lotfi- Tokaldany, Farzad Masoudkabir, Babak Sattartabar, Maryam Masoudi, Akbar Shafiee, Reza Mohseni Badalabadi, Mina Pashang, Afsaneh Aein, Masih Tajdini
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran


OBJECTIVE
Acute ischemic cardiac events can complicate coronavirus disease 2019 (COVID-19). We report the in-hospital characteristics of patients with acute myocardial infarction and concomitant COVID-19.

METHODS
This was a registry-based retrospective analysis of patients admitted with positive COVID-19 tests who suffered acute myocardial infarction either before or during hospitalization; from 1 March 2020 to 1 April 2020 in a tertiary cardiovascular center—Tehran Heart Center. We performed an exploratory analysis to compare the clinical characteristics of patients who died during hospitalization or were discharged alive.

RESULTS
In March 2020, 57 patients who had acute myocardial infarction and a confirmed diagnosis of COVID-19 were included in the study. During hospitalization, 13 patients (22.8%) died after a mean hospital stay of 8.4 days. The deceased were older than the survivors. No significant association between mortality and sex or length of hospital stay was observed. Hypertensive individuals were more likely to have a fatal outcome. Previously receiving angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers did not show any association with mortality. Regarding the laboratory data during hospitalization, higher cardiac troponin T, neutrophil count, C-reactive protein, urea, and blood urea nitrogen/creatinine ratio were observed in the mortality group. The deceased had a lower lymphocyte count than the survivors.

CONCLUSIONS
Markers of worsening renal function and immune system disturbance seem to be associated with mortality in concurrent acute myocardial infarction and COVID-19. Optimizing the management of acute coronary syndrome complicating COVID-19 requires addressing such potential contributors to mortality.

Keywords: Myocardial infarction, acute coronary syndrome, Coronavirus disease 2019, covid 19

How to cite this article
Hamed Tavolinejad, Kaveh Hosseini, Saeed Sadeghian, Hamidreza Pourhosseini, Masoumeh Lotfi- Tokaldany, Farzad Masoudkabir, Babak Sattartabar, Maryam Masoudi, Akbar Shafiee, Reza Mohseni Badalabadi, Mina Pashang, Afsaneh Aein, Masih Tajdini. Clinical implications and indicators of mortality among patients hospitalized with concurrent COVID-19 and myocardial infarction. Turk Kardiyol Dern Ars. 2021; 49(4): 293-302

Corresponding Author: Masih Tajdini, Iran
© Copyright 2021 Archives of the Turkish Society of Cardiology
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