Wild type transthyretin cardiac amiloidozis as a rare and overlooked underlying etiology in a patient with heart failure with preserved ejection fraction and left ventricular hypertrophy [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2021; 49(7): 579-584 | DOI: 10.5543/tkda.2021.09310

Wild type transthyretin cardiac amiloidozis as a rare and overlooked underlying etiology in a patient with heart failure with preserved ejection fraction and left ventricular hypertrophy

Selda Murat1, Yüksel Çavuşoğlu1, İlknur Ak Sivrikoz2
1Eskişehir Osmangazi University, Faculty of Medicine, Department of Cardiology, Eskişehir
2Eskişehir Osmangazi University, Faculty of Medicine, Department of Nuclear Medicine, Eskişehir

Cardiac amyloidosis (CA) is a rare, progressive, infiltrative and restrictive cardiomyopathy characterized by extracellular deposition of insoluble amyloid fibrils in the form of misfolded endogenous proteins in the heart. The most common types of CA are transthyretin (TTR) and immunoglobulin light chain (AL) amyloidosis. TTR-CA is further subdivided into wild-type (wtTTR-CA) and mutant (mTTR-CA) forms. CA has long been thought to be a rare disease. However, in clinical practice, it is frequently overlooked, but increasingly recognized as the cause of heart failure with preserved ejection fraction (HFpEF). Patients with CA show poor prognosis. Early diagnosis and novel therapeutic options have been shown to significantly improve prognosis. Novel diagnostic modalities such as nuclear scintigraphy allow the earlier diagnosis of TTR-CA without a biopsy. In this report, we present a case of wtTTR-CA as a rare and overlooked underlying etiology of HFpEF and left ventricular hypertrophy.

Keywords: Transtretine cardiac amiloidozis, heart failure, left ventricular hypertrophy

How to cite this article
Selda Murat, Yüksel Çavuşoğlu, İlknur Ak Sivrikoz. Wild type transthyretin cardiac amiloidozis as a rare and overlooked underlying etiology in a patient with heart failure with preserved ejection fraction and left ventricular hypertrophy. Turk Kardiyol Dern Ars. 2021; 49(7): 579-584

Corresponding Author: Yüksel Çavuşoğlu, Türkiye
© Copyright 2021 Archives of the Turkish Society of Cardiology
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