ISSN 1016-5169 | E-ISSN 1308-4488
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The Importance of Nitric Oxide and Oxidative Stress in Atrial High-Rate Episodes in Patients with Cardiac Devices [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(2): 81-87 | DOI: 10.5543/tkda.2023.07433

The Importance of Nitric Oxide and Oxidative Stress in Atrial High-Rate Episodes in Patients with Cardiac Devices

İnanç Artaç1, Metin Öğün2, Timor Omar1, Muammer Karakayalı1, Doğan İliş1, Ayça Arslan1, Yavuz Karabağ1, İbrahim Rencüzoğulları1
1Department of Cardiology, Kafkas University Faculty of Medicine, Kars, Türkiye
2Department of Biochemistry, Kafkas University Faculty of Medicine, Kars, Türkiye


OBJECTIVE
Atrial High Rate Episodes (AHRE) are subclinical atrial tachyarrhythmias detectable by cardiac implantable electronic devices (CIEDs). AHREs have been associated with an increased risk of developing atrial fibrillation (AF), thromboembolism, cardiovascular and cerebrovascular events, and mortality. Although recent studies have assessed the value of oxidative stress markers in patients with AF, the relationships between AHRE and oxidative stress markers, including nitric oxide, has not yet been elucidated. This study aims to investigate the relationship between these markers and AHRE.


METHOD
This prospective, cross-sectional study comprised 180 patients with CIEDs. The study population was divided into two groups based on the presence (n = 78) and absense (n = 102) of AHRE to analyze its association with biomarkers.


RESULTS
The AHRE (+) group was significantly older, had a higher prevalence of hypertension, higher NT-proBNP (508.8 ± 249 pg/mL vs. 415.3 ± 292.1; P = 0.037), MDA levels (20.9 ± 4.1 μmol/L vs. 19.1 ± 3.1 μmol/L; P = 0.006), and iNOS activity (1,935.9 ± 326.1 pg/mL vs. 1,677.4 ± 363.2 pg/mL; P < 0.001). Logistic regression analysis identified age, hypertension, MDA (odds ratio [OR]: 1.131, 95%CI: 1.009 - 1.268, P = 0.035), inducible nitric oxide synthase (iNOS) activity (OR = 1.002, 95% CI = 1.001 - 1.003, P < 0.001), and endothelial nitric oxide synthase (eNOS) activity (OR = 0.990, 95% CI = 0.986 - 0.984, P < 0.001) as independent predictors of AHRE.


CONCLUSION
The study findings indicated that plasma levels of NT-proBNP, MDA, nitric oxide, and the expression of iNOS and eNOS were significantly associated with AHRE. Moreover, elevated plasma MDA concentrations, increased iNOS activity, and decreased eNOS activity were identified as independent predictors of AHRE.

Keywords: Atrial high rate episodes, nitric oxide, malondialdehyde, inducible nitric oxide synthase, endothelial nitric oxide synthase

How to cite this article
İnanç Artaç, Metin Öğün, Timor Omar, Muammer Karakayalı, Doğan İliş, Ayça Arslan, Yavuz Karabağ, İbrahim Rencüzoğulları. The Importance of Nitric Oxide and Oxidative Stress in Atrial High-Rate Episodes in Patients with Cardiac Devices. Turk Kardiyol Dern Ars. 2024; 52(2): 81-87

Corresponding Author: İnanç Artaç
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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