Gallopamil Treatment in Chronic Stable Angina Pectoris: A Double Blind, Placebo-Controlled Study

Antiangial effect of gallopamil was investigated as a double blind, placebo-controlled study in 14 patients with chronic stable angina pectoris (10 men, 4 women, mean age 53.8±9.1). Ergometric exercise stress test was performed in all patients before and after two-week drug or placebo periods. Number of anginal attacks per week and nitrate consumption declined after gallopamil when compared to placebo (81% and 79%; p<0.001 and p<0.01). Resting heart rate, systolic and diastolic blood pressures statistically significantly diminished after gallopamil therapy (p<0.005 and p<0.01). While resting ratepressure product walues were less than that of placebo period in gallopamil period, exercise tolerance increased 36% after gallopamil treatment compared with placebo. Also the amount of ST segment depression significantly decreased in patients receiving gallopamil (p<0.001). It was concluded that, gallopamil is an effective agent in the treatment of chronic stable angina pectoris.