Turk Kardiyol Dern Ars. 2013; 41(7): 617-624 | DOI: 10.5543/tkda.2013.68625

Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio

Ayhan Erkol¹, Selçuk Pala², Vecih Oduncu³, Alev Kılıcgedik², Filiz Kızılırmak⁴, Can Yücel Karabay², Ahmet Güler², Cevat Kırma^2
1Department of Cardiology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey
²Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey
³Department of Cardiology Fatih Medikal Park Hospital, Istanbul
⁴Department of Cardiology, Medipol University Hospital, Istanbul

OBJECTIVES
Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20±3 months after acute MI.

STUDY DESIGN
58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated.

RESULTS
The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were significantly correlated with left ventricular ejection fraction (LVEF) (ρ=0.34, p=0.009), end diastolic volume index (EDVi) (ρ=-0.39, p=0.002) and end systolic volume index (ESVi) (ρ=-0.40, p=0.002).

CONCLUSION
Plasma MMP-8 levels were found to still be high in post-MI patients 20±3 months after the index event. The levels were significantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function.

Keywords: Cardiac volume, coronary disease, biological markers/ blood, electrocardiography; ejection fraction; heart ventricles; matrix metalloproteinase 8; myocardial infarction/blood/enzymology.

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