Interrelations Between Echocardiographic Measurements of Left Ventricle, Left Atrium, Ascending Aorta, Defect Diameter and Pulmonary Arterial Pressure in Isolated Ventricular Septal Defect

Diameters of VSD (VSDd), left ventricle (LVD), left atrium (LAd) and ascending aorta (AsAod) as well as right ventricular systolic pressure (RVP) which was determined from LV-RV gradient were measured in 58 isolated VSD patients by color flow Doppler, two-dimensional and M-mode echocardiography. Body surface area (BSA) was estimated from weight. In addition to the above variables, quotient parameters such as VSDd/BSA, LVd/Aod, LAd/Aod, LAd/BSA, LVd/BSA, Aod/BSA were derived. Linear interrelationships were calculated between the above mentioned parameters including their relationship with age. Weighted determinants of the following pure parameters such as VSDd, LVD, LAd, AsAod and RVP were established by multifactorial analysis. According to the results, VSDd was very significantly and positively correlated with RVP and LAd (multiple r=0.75). Its negative relationship with BSA and positive relationship with AsAod (r=0.20) were not found to be significant. RVP is correlated positively with VSD, its square, as well as LVd and inversely with BSA (multiple r=0.73). LAD and AsAod are not primary factors influencing RVP. LAd goes parallel with LVd, VSDd and AsAod (multiple r=0.79). BSA and RVP are not primary factors influencing LAd in VSD. LVd goes parallel with BSA, LAd and RVP (multiple r=0.79). LAd is a better determinant of VSDd than is LVd. AsAod is mainly related with BSA, i.e. with growth (r=0.79). LAd makes a small contribution to this estimation (multiple = 0.79). On the other hand, VSDd, RVP and LVd are not primary factors influencing AsAo. Assessment of the relationship between echocardiographically determined diameters of left ventricle, left atrium, ascending aorta, defect size and pulmonary artery pressure in isolated ventricular septal defect.