Turk Kardiyol Dern Ars. 2012; 40(4): 316-322 | DOI: 10.5543/tkda.2012.81557

The relationship between serum total testosterone and 24-hour urinary sodium excretion in never-treated stage 1 essential hypertensive patients

Barış Afşar¹, Mahmut Ay², Rukuye Burucu³, Alper Kırkpantur^4
1Department of Nephrology, Konya Numune State Hospital, Konya, Turkey
²Department of Biochemistry, Konya Numune State Hospital, Konya, Turkey
³Department of Nursery, Konya Numune State Hospital, Konya, Turkey
⁴RFM Dialysis Center, Ankara, Turkey

OBJECTIVES
To study the relationship between serum total testosterone (TT) and 24-hour urinary sodium excretion in newly diagnosed stage 1 essential hypertensive patients with normal renal function.

STUDY DESIGN
In total, 80 never-treated stage 1 hypertensive patients were included. All patients provided medical history and underwent physical examination, blood pressure measurement, 12-lead electrocardiography, routine urine analysis, biochemical analysis, 24-hour urine collection to measure urinary sodium and protein excretion, and creatinine clearance calculation.

RESULTS
Pearson correlation analysis revealed that logarithmically converted 24-hour urinary sodium excretion was correlated with age (r=-0.399, p<0.0001), body mass index, (r=0.304, p=0.006), systolic blood pressure (r=0.394, p<0.0001), serum potassium (r=0.233, p=0.037), creatinine clearance (r=0.600, p<0.0001), and logarithmically converted serum TT (r=-0.272, p=0.015). Stepwise linear regression analysis revealed that age (p<0.0001), creatinine clearance (p=0.015), systolic blood pressure (p<0.0001), potassium (p=0.021), and serum TT (p=0.002) were independently related to logarithmically converted 24-hour sodium excretion.

CONCLUSION
We demonstrated that serum TT levels were independently related to 24-hour urinary sodium amount.

Keywords: Blood pressure, body mass index, hypertension, hypertensive patients; renal function; sodium chloride/adverse effects; sodium/urine; total testosterone

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