Hematological Incidies May Predict Oxidative Stress in Patients with ST-segment Elevation Myocardial Infarction

OBJECTIVE
Oxidative stress is closely related to the development of atherosclerosis and acute coronary syndromes. In this study, we aimed to examine the relationship between hemogram indices and oxidative stress parameters in patients with ST-segment elevation myocardial infarction.


METHODS
A single-centered, prospective, and cross-sectional study was performed in 61 patients with ST-segment elevation myocardial infarction. Before coronary angiography, in the blood samples taken from the peripheral vein, hemogram indices and oxidative stress parameters such as total oxidative status, total antioxidant status, and oxidative stress index were examined. We examined a total of 15 hemogram indices.


RESULTS
Most of the study patients were male (78%), and the mean age was 59.3 ± 12.2 years. Mean corpuscular volume value was found to be negatively and moderately significantly correlated with total oxidative status and oxidative stress index values (r = −0.438, r = −0.490, P < 0.001). A negative and moderate significant correlation was found between mean corpuscular hemoglobin and total oxidative status and oxidative stress index values (r = −0.487, r = −0.433, P < 0.001). Red cell distribution width value was found to be positively and moderately correlated with total oxidative status (r = 0.537, P < 0.001). Red cell distribution width was also found to be moderately and statistically significantly correlated with oxidative stress index value (r = 0.410, P = 0.001). In receiver operating characteristic analysis, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width levels have been successful in predicting total oxidative status and oxidative stress index.


CONCLUSIONS
We conclude that mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width levels predict oxidative stress in patients with ST-segment elevation myocardial infarction.