Turk Kardiyol Dern Ars. 2007; 35(1): 21-27

The effect of coronary angioplasty on oxidative and antioxidative status

Mustafa Gür¹, Ali Yıldız¹, Recep Demirbağ¹, Remzi Yılmaz¹, Altan Koç², Ekrem Karakaya³, Hakim Celik⁴, Şahbettin Selek⁴, Özcan Erel^4
1Harran University, Faculty Of Medicine, Department Of Cardiology, Sanliurfa.
²State Hospital, Department Of Cardiology, Kırsehir
³Erciyes University, Faculty Of Medicine, Department Of Cardiology, Kayseri.
⁴Harran University, Faculty Of Medicine, Department Of Clinical Biochemistry, Sanliurfa.

OBJECTIVES
We investigated the alterations in oxidative and antioxidative status during coronary angioplasty and coronary angiography interventions.

STUDY DESIGN
The study included 28 consecutive patients (20 males, 8 females; mean age 58.4 years) who underwent elective percutaneous transluminal coronary angioplasty (PTCA) for a single coronary stenosis. Nineteen patients with normal coronary angiography comprised the control group. Coronary angiography and PTCA were performed according to the standard protocols. Blood samples were taken just before and at 1 to 2 hours after coronary interventions to determine parameters of serum oxidative status including total oxidant status (TOS), lipid hydroperoxide levels, and oxidative stress index (OSI). For antioxidative status, total antioxidant capacity (TAC) and total free sulfhydryl groups were determined.

RESULTS
Before coronary interventions, indicators of oxidative stress (TOS, lipid hydroperoxides, and OSI) were higher (p<0.001, p=0.029, p<0.001, respectively), and TAC (p=0.032) and free sulfhydryl levels (p=0.01) were lower in the PTCA group. After PTCA, TOS, lipid hydroperoxides, and OSI showed significant increases (p=0.016, p=0.002, p=0.003, respectively), whereas TAC (p=0.039) and free sulfhydryl levels (p=0.03) were significantly decreased. However, in the control group, none of the parameters changed significantly following angiography (p>0.05). In the PTCA group, a significant positive correlation was found between changes in OSI and total inflation time (r=0.554, p=0.002).

CONCLUSION
Our findings demonstrate that PTCA is associated with increased oxidative stress through ischemia-reperfusion effect, whose severity is related with total inflation time.

Keywords: Angioplasty, transluminal, percutaneous coronary, antioxidants; coronary disease; free radicals; lipid peroxidation; myocardial reperfusion injury; oxidative stress

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