Turk Kardiyol Dern Ars. 2024; 52(1): 27-35 | DOI: 10.5543/tkda.2023.73480

Different Cardio-Selective ß-Blockers and the Prevention of Exaggerated Blood Pressure Response During Exercise: A Retrospective Cross-Sectional Study

Gurbet Özge Mert, Emre Şener, Ahmet Serdar Yılmaz, Furkan Yetmiş, Ezgi Çamlı, Fatih Enes Durmaz, Muhammet Dural, Yüksel Çavuşoğlu, Selda Murat, Bülent Görenek, Kadir Uğur Mert
Department of Cardiology, Eskişehir Osmangazi University, Faculty of Medicine, Eskişehir, Türkiye

OBJECTIVE
The aim of this study was to analyze the role of various ß-blockers in managing exercise-induced blood pressure escalations, referred to as exaggerated blood pressure response (eBPR). Despite the importance of this phenomenon, there is limited data on the efficacy of ß-blockers in controlling eBPR.


METHOD
Our retrospective cohort for this study comprised 2,803 individuals who underwent treadmill tests from January 2016 to February 2018. A further subgroup analysis of 1,258 patients receiving ß-blocker treatment was performed to evaluate the influence of different ß-blockers on eBPR.


RESULTS
The results demonstrated that ß-blockers play a significant role in mitigating the occurrence of eBPR (P = 0.026), irrespective of the specific type of ß-blocker. Additionally, no significant variance was observed in the development of eBPR among the different ß-blocker groups (P = 0.532 for systolic blood pressure (BP); P = 0.068 for diastolic BP). This finding remained consistent even among the 992 hypertensive patients, where no notable association was found between the type of ß-blocker and the development of eBPR (P = 0.736 for systolic BP; P = 0.349 for diastolic BP). It is noteworthy that patients using ß-blockers had unique clinical and demographic attributes.


CONCLUSION
Our study suggests that ß-blockers can potentially deter the development of eBPR during physical activity, a benefit that is consistent across all types of ß-blockers. The study sheds light on prospective randomized studies on the use of eBPR as a new treatment target.

Keywords: Blood pressure, exaggerated blood pressure, blood pressure response to exercise, beta-blockers, atenolol, metoprolol, bisoprolol, carvedilol, nebivolol

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