Case Report Torsade de Pointes in a Case With Secondary Hypothyroidism

A woman with partial hypopituitarism, secondary hypothyroidism and a slightly prolonged QTc interval was monitorized with the expectation of derecting rhythm abnormalities. Torsade de pointes and subsequent ventricalar fibrillation were observed and treated before thyroid hormone replacement therapy was begun. Since adrenal deficiency was excluded and the QTc value did not seem to be afected by the antiarrhythmic agents administered to the patient, hypothyroidism was regarded as the main cause of the ventricular arrhythmias. Disopyramide could have been a contributory factor. The QTc interval returned to normal with the treatment of hypothyroidism.