Turk Kardiyol Dern Ars. 2006; 34(1): 55-58

Is cell transplantation for cardiac regeneration arrhythmogenic?

Erdem Diker
Ankara Numune Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, Ankara

Cardiac cell transplantation for cardiac regeneration has yielded promising results in recent years. This method consists of epicardial, endocardial, or transcoronary transplantation of mainly skeletal myoblasts or bone marrowderived stem cells into the heart. Promising results have been reported with this novel treatment, especially concerning improvement in left ventricular function. However, serious limitations have been encountered following this therapy, the most important of which is the emergence of malignant ventricular arrhythmias. Interestingly, surgerybased epicardial or catheter-based endocardial transplantations of autologous skeletal myoblasts have been associated with the development of arrhythmias while catheterbased transcoronary transplantation of stem cells has not been found to increase arrhythmia risk. After ali, the ques- tion of arrhythmogenic potential of celi transplantation has yet to be resolved.

Keywords: Arrhythmia/etiology, myoblasts, skeletal/transplanta- tion; myocardial infarction; stem celi transplantation/methods/ adverse effects; tissue therapy/methods; ventricular function, left.

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