Turk Kardiyol Dern Ars. 2020; 48(5): 472-483 | DOI: 10.5543/tkda.2020.53849

Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention

Reza Kiani¹, Sanam Alilou², Shirin Rafatnia², Yasaman Taslimi³, Sima Habibzadeh³, Safoora Gharibzadeh⁴, Ata Firouzi¹, Shahin Rahim¹, Ali Zahedmehr¹, Farzaneh Mehrvarz¹, Mehrdad Moghadam Ahari¹, Parham Sadeghipour^1
1Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran
²Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
³Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran
⁴Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran

OBJECTIVE
The aim of the present study was to examine the association between 2 polymorphisms of the endothelial nitric oxide (eNOS) gene (-786T>C and +894G>T) and the no-reflow/slow-flow phenomenon in post-primary percutaneous coronary intervention (PPCI) patients.

METHODS
A total of 103 post-PPCI patients were enrolled. Coronary no-reflow phenomenon was defined as a Thrombolysis in Myocardial Infarction (TIMI) flow grade 0–1 and coronary slow-flow phenomenon (CSFP) was defined as a TIMI flow grade ≤2.

RESULTS
Due to the small number of post-PPCI patients with the no-reflow phenomenon (n=4), the primary comparison was made between CSFP (n=20) and normal flow (n=83) groups. There was a greater frequency of CSFP among carriers of the –786C allele of the eNOS –786T>C polymorphism (odds ratio [OR]: 3.90; 95% confidence interval [CI]: 0.87–17.45; p=0.07). However, no such association was detected between the +894T allele of the eNOS +894G>T and CSFP (OR: 0.92; 95% CI: 0.21–3.98; p=0.91). In the adjusted analysis, the -786T>C polymorphism did not reach statistical significance.

CONCLUSION
There was no significant association between CSFP and 2 of the most common polymorphisms of the eNOS gene in post-PPCI patients.

Keywords: Endothelial nitric oxide, gene polymorphism; no reflow; primary percutaneous coronary intervention; slow flow; ST-segment elevation myocardial infarction.

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