ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Evaluation of subclinical atherosclerosis in chronic sinusitis patients [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(3): 234-241 | DOI: 10.5543/tkda.2015.84584

Evaluation of subclinical atherosclerosis in chronic sinusitis patients

Musa Çakıcı1, Yasin Sarıkaya2, Mustafa Çetin1, Mehmet Karataş2, Adnan Doğan3, Sedat Doğan2, Emin Kaskalan2, Mustafa Polat1, Hakan Taşolar1, Sabri Abuş1
1Department Of Cardiology, Adiyaman Universty, Adiyaman, Turkey
2Department Of Ent, Adiyaman Univesity, Adiyaman, Turkey
3Department Of Cardiology, Dumlupinar Universty, Kütahya, Turkey


OBJECTIVE
This study aimed to assess the impact of chronic sinusitis (CS) on carotid-intima-media thickness (CIMT), a marker of early atherosclerotic changes in the arterial bed.

METHODS
The study included 50 patients with CS (25 male, 25 female, mean age 26.6±5.34 years), and 50 healthy subjects (25 male, 25 female, mean age 25.8±4.76 years), aged 18 to 35 years without atherosclerotic risk factors, normal body mass index and normal metabolic parameters. CIMT was measured in all patients by ultrasonography. CS was confirmed by medical history and computed tomography scan of the paranasal cavities.

RESULTS
No significant difference existed between the groups in terms of age, sex, body mass index (BMI), waist circumference, plasma creatinine, glucose, low-density lipoprotein (LDL), highdensity lipoprotein (HDL) cholesterol values (p>0.05). However, mean values of CIMT (mm) were significantly greater in CS patients than in healthy subjects (0.51±0.09 vs. 0.40±0.07, p<0.001). Duration of CS disease was 6.0 (3.0-13.0) years. Significant correlation was found between CIMT mean values and age, BMI, waist circumference, HDL and LDL-cholesterol values and duration of CS (r=0.413; p<0.001, r=0.353; p<0.001, r=0.355; p<0.001, r=-0.266; p=0.007, r=0.327; p<0.001 and r=0.425; p=0.002 respectively). Multiple linear regression analysis revealed that waist circumference, HDL and LDL-cholesterol and duration disease of CS were independent predictors of CIMT (β=0.523; p=0.001, β=-0.176; p=0.045, β=0.297; p=0.002, and β=0.436; p<0.001, respectively).

CONCLUSION
Our cross-sectional study revealed the presence of a negative effect of CS on the atherosclerotic process. Therefore, it is believed that effective treatment of CS may be beneficial in slowing the process of atherosclerosis.

Keywords: Atherosclerosis, carotid intima-media thickness; chronic sinusitis; inflammation

How to cite this article
Musa Çakıcı, Yasin Sarıkaya, Mustafa Çetin, Mehmet Karataş, Adnan Doğan, Sedat Doğan, Emin Kaskalan, Mustafa Polat, Hakan Taşolar, Sabri Abuş. Evaluation of subclinical atherosclerosis in chronic sinusitis patients. Turk Kardiyol Dern Ars. 2015; 43(3): 234-241

Corresponding Author: Musa Çakıcı, Türkiye
Manuscript Language: Turkish


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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