ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Effect of Sacubutril/Valsartan and Dapagliflozin on Cardiac Functions and Exercise Capacity of Rats [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-74353 | DOI: 10.5543/tkda.2024.74353

Effect of Sacubutril/Valsartan and Dapagliflozin on Cardiac Functions and Exercise Capacity of Rats

Akın Torun1, Şahhan Kılıç1, Süha Asal1, Mert Babaoğlu1, Samet Yavuz1, Cumaali Demirtaş2, Serkan Dilmen3, Ahmet Lutfullah Orhan1, Mehmet Uzun1
1Department of Cardiology, Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul, Türkiye
2Veterinary Medicine, Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul, Türkiye
3Department of Cardiology, Izmir Bayraklı City Hospital, Izmir, Türkiye


BACKGROUND
Studies conducted in recent years have demonstrated the positive effects of sacubitril/valsartan and dapagliflozin on cardiac prognosis and performance. These drugs can potentially be abused as doping agents by professional athletes. In our study, we evaluated the effects of sacubitril/valsartan and dapagliflozin on athletic performance.

METHODS
In the study, the swimming performances of three groups of rats were evaluated by dividing them into control, sacubitril/valsartan and dapagliflozin groups. Additionally, echocardiography, weight and rotarod data were evaluated during follow-up.

RESULTS
In the comparison of sacubitril/valsartan and control groups, a statistical difference was seen in the 13th, 19th and 20th swimming sessions, and when the total and median swimming times were compared, the p values were 0.115 and 0.015. In the comparison of dapagliflozin and control groups, a statistical difference was observed starting from the 10th swimming session, and when the total and median swimming times were compared, the p values were <0.001 and <0.001. In triple analysis, a statistical difference was seen from the 9th swimming session until the end of the experiment. Furthermore, a statistical difference was observed in rotarod results for sacubitril/valsartan and dapagliflozin compared to baseline. (p value <0.001 and 0.011 respectively)

CONCLUSION
Our study showed a limited positive effect of sacubitril/valsartan on athletic performance. The impact of dapagliflozin on athletic performance was shown to be particularly significant.

Keywords: Athletic performance, dapagliflozin, doping agents, performance enhancing, sacubitril/valsartan, sports cardiology

Corresponding Author: Akın Torun
Manuscript Language: English
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Journal Citation Indicator: 0.18
CiteScore: 1.1
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