Turk Kardiyol Dern Ars. 2006; 34(2): 89-93
DNA damage and plasma total antioxidant capacity in patients with slow coronary artery flow
, Remzi Yılmaz1
, Mustafa Gür Gür1
, Alper Sami Kunt2
, Abdurrahim Koçyiğit3
, Hakim Çelik3
, Salih Güzel3
, Sahabettin Selek31
Departments of Cardiology Medicine Faculty of Harran University, Şanlıurfa2
Departments of Cardiovascular Surgery Medicine Faculty of Harran University, Şanlıurfa3
Departments of Clinical Biochemistry Medicine Faculty of Harran University, Şanlıurfa
OBJECTIVES Although clinical and pathophysiologic features of slow coronary artery flow (SCAF) have been previously described, the underlying pathophysiology has not been fully elucidated. The aim of this study was to investigate the association between DNA damage and SCAF.
STUDY DESIGN The study was comprised of 23 patients with SCAF and 23 healthy volunteers. DNA damage was assessed by the alkaline comet assay in peripheral lymphocytes and plasma total antioxidant capacity (TAC) was determined by a novel, automated method.
RESULTS Although DNA damage was higher in the SCAF group than in controls, this did not reach significance (106.6±38.2 AU vs 80.5±51.7 AU; p=0.055). Similarly, TAC levels did not differ significantly between the two groups (1.32±0.32 mmol Trolox equiv./L vs 1.35±0.26 mmol Trolox equiv./L, p=0.667). In the patient group, DNA damage showed a positive correlation with age (r=0.775, p<0.001) and a negative correlation with TAC (r=-0.791, p<0.001) and HDL cholesterol levels (r=-0.456, p= 0.029). In multiple linear regression analysis, TAC and age were found to be independent predictors of DNA damage in patients with SCAF.
CONCLUSION These findings indicate that SCAF is not associated with increased DNA damage and decreased TAC, suggesting that DNA damage may not be useful in the differential diagnosis of SCAF.
Antioxidants, coronary circulation, coronary artheriosclerosis/blood, DNA damage.
How to cite this article
Recep Demirbağ, Remzi Yılmaz, Mustafa Gür Gür, Alper Sami Kunt, Abdurrahim Koçyiğit, Hakim Çelik, Salih Güzel, Sahabettin Selek. DNA damage and plasma total antioxidant capacity in patients with slow coronary artery flow. Turk Kardiyol Dern Ars. 2006; 34(2): 89-93
Corresponding Author: Recep Demirbağ, Türkiye