ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
pdf
Fourier Transformation Analysis of Atrial Fibrillation Intervals Following Ibutilide and Procainamide to Predict Successful Cardioversion [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2001; 29(8): 481-487

Fourier Transformation Analysis of Atrial Fibrillation Intervals Following Ibutilide and Procainamide to Predict Successful Cardioversion

Ata KIRILMAZ1, Kürşad ERİNÇ2, Fethi KILIÇARSLAN2, Ertan DEMİRTAŞ2
1
2

The frequency and the degree of fractionation of intraatrial recordings during atrial fibrillation (AF) have a correlation with the wavelengths and the size of the reentry pathways. We hypothesized that spectral ana lysis might help to explain the mechanism of antiarrhythmic drug- induced termination of AF. The frequency spectrum of monophas ic action potenti als recorded in the right atrium was ana lysed us ing Fast Fourier Transformatian (FFT). The maximal, minimal, first 5 peak frequencies and the width of frequency distribution within each 5 see segments were calculated before and after placebo (group C, n=7), ibut il ide 1.6±0.4 mg (group I, n= IO) or procainamide 1240±221 mg (group P, n= 10) infusion in 24 patients with AF. Age (66±9, 68±6 and 64±7), LA size (40±8, 44±5 and 46±4 mm) and LV EF (44± 11 , 43±7 and 40±11) were s imilar in group I, P and C, respectively (p>0.05). Ibutilide and procainamide decreased the peak AF frequency from 6.2±0.6 and 6.5±1.1 Hz to 4.3±0.3 and 4.5±0.8 Hz, respectively (p<0.00 1), whereas placebo had no effect on FFT. Ibutilide decreased the frequency of the peaks significantly within 30 see after each dose. In 3 patients in group I, AF terminated. Cardioverted patients tented to have a lower frequency at baseline than nonconverters (5.7±.3 vs. 6.4±.6 Hz). Ibutilide decreased the frequency of AF to 3.5±0.1 Hz before cardioversion.
CONCLUSIONS
Fourier transformatian analysis of AF electrograms is a useful method for evaluation of the effect of drugs on atrial tissue. Ibutilide may decrease the frequency of AF to a critica! level before cardioversion.

Keywords: Atrial fibrillation, monophasic action potential, Fast Fourier transformatian

How to cite this article
Ata KIRILMAZ, Kürşad ERİNÇ, Fethi KILIÇARSLAN, Ertan DEMİRTAŞ. Fourier Transformation Analysis of Atrial Fibrillation Intervals Following Ibutilide and Procainamide to Predict Successful Cardioversion. Turk Kardiyol Dern Ars. 2001; 29(8): 481-487
Manuscript Language: Turkish


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.