Turk Kardiyol Dern Ars. 2020; 48(2): 96-102 | DOI: 10.5543/tkda.2019.92735
Prevalence of inappropriate sinus tachycardia and the comparison of the heart rate variability characteristics with propensity score-matched controls
, Benay Ozbay1
, Inan Mutlu1
, Ecem Gurses1
, Hatice S Kemal2
, Burcu Yagmur1
, Levent Hürkan Can11
Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey2
Department of Cardiology, Near East University Faculty of Medicine, Lefkose, Turkish Republic of Northern Cyprus
OBJECTIVE Inappropriate sinus tachycardia (IST) is a syndrome characterized by an elevated resting heart rate with distressing symptoms and no secondary cause of sinus tachycardia. This study was conducted to evaluate both the prevalence of IST among symptomatic patients and heart rate variability (HRV) characteristics.
METHODS The records of all consecutive symptomatic patients who had undergone 24-hour Holter monitoring between September 2015 and November 2016 at a single center were retrospectively evaluated. IST was defined as a 24-hour mean heart rate (HR) of ≥90 beats/minute and a resting HR of ≥100 beats/minute in the absence of any secondary cause of sinus tachycardia. All of the study data related to clinical characteristics, symptoms, concomitant diseases, and Holter electrocardiogram parameters were obtained from the electronic hospital records. A propensity age- and sex-matched control group was selected from a non-IST patient cohort.
RESULTS A total of 1865 consecutive patients were evaluated and 32% were excluded due to an inadequate Holter recording period or insufficient quality, atrial fibrillation episodes, atrioventricular block, or >1% atrial or ventricular extrasystoles. Among 1265 patients with sinus rhythm, 4.98% (n=63) had IST. The IST patients were younger (39.6±17.4 vs. 50.2±17.2 years; p<0.001), and female gender was more prominent (60.3% vs. 43.8%; p=0.009). All of the time and frequency domain parameters of HRV except the low frequency/high frequency ratio were significantly reduced in the IST group compared with the propensity-matched controls.
CONCLUSION The IST prevalence among symptomatic patients in sinus rhythm was 4.98%. IST was primarily seen in younger women, and they had diminished time and frequency domain HRV parameters.
Epidemiology, heart rate variability; Holter electrocardiogram; inappropriate sinus tachycardia.
How to cite this article
Evrim Şimşek, Benay Ozbay, Inan Mutlu, Ecem Gurses, Hatice S Kemal, Burcu Yagmur, Levent Hürkan Can. Prevalence of inappropriate sinus tachycardia and the comparison of the heart rate variability characteristics with propensity score-matched controls. Turk Kardiyol Dern Ars. 2020; 48(2): 96-102
Corresponding Author: Evrim Şimşek, Türkiye