Turk Kardiyol Dern Ars. 2021; 49(1): 60-66 | DOI: 10.5543/tkda.2020.74670
Assessment of epicardial adipose tissue thickness and total calcium score in sarcoidosis patients
Mehmet Sait Altıntaş1
, Emine Altuntaş2
, Ferhat Eyyupkoca3
, Ibrahim Taşkın Rakıcı4
, Barış Demirkol5
, Erdoğan Çetinkaya5
, Turgut Karabag61
Department of Cardiology, Yedikule Chest Disease and Thoracic Surgery Training Research Hospital, İstanbul, Turkey2
Department of Cardiology, Büyükçekmece Mimar Sinan State Hospital, İstanbul, Turkey3
Department of Cardiology, University of Health Sciences İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Training and Research Hospital, İstanbul, Turkey4
Department of Radiology, İstanbul Education Research Hospital, İstanbul, Turkey5
Department of Pulmonology, Yedikule Chest Disease and Thoracic Surgery Training Research Hospital, İstanbul, Turkey6
Department of Cardiology, İstanbul Education Research Hospital, İstanbul, Turkey
OBJECTIVE Increased thickness of epicardial adipose tissue (EAT) and the total coronary artery calcium score (TCACS) are independent predictors of atherosclerosis. The aim of this study was to investigate whether EAT thickness, measured using thoracic computed tomography, and TCACS were greater in patients with sarcoidosis.
METHODS This was a retrospective study. The details of participants who presented at the cardiology and pulmonology outpatient clinics between January 2011 and December 2018 with dyspnea, chest pain, or palpitations from the hospital data system were reviewed. Patients with transthoracic echocardiography and thorax computed tomography (CT) (CT) records were identified, and those who were diagnosed with sarcoidosis, had no other health problems, and did not take any medication were included in the study.
RESULTS A total of 45 controls and 78 sarcoidosis patients were enrolled. The mean age of the controls was 46.15±13.1 years, while it was 46.26±12.37 years in the sarcoidosis group, which represented no significant difference between the groups (p>0.05). When the groups were compared in terms of a fasting blood test, erythrocyte sedimentation rate (ESR), TCACS, EAT thickness, levels of C-reactive protein (CRP), total cholesterol, low-density lipoprotein (LDL), and triglycerides, it was observed that CRP and EAT thickness were higher in the sarcoidosis group.
CONCLUSION The results of this study indicated that the thickness of EAT calculated using thorax CT was greater in sarcoidosis patients; however, the TCACS was similar in both groups. In addition, there was a positive correlation between EAT thickness and the level of total cholesterol, LDL, triglycerides, CRP, and the sedimentation rate. These findings suggest that atherosclerosis may start earlier in those with sarcoidosis than in the healthy population.
Atherosclerosis, epicardial adipose tissue thickness; sarcoidosis; total coronary calcium score.
How to cite this article
Mehmet Sait Altıntaş, Emine Altuntaş, Ferhat Eyyupkoca, Ibrahim Taşkın Rakıcı, Barış Demirkol, Erdoğan Çetinkaya, Turgut Karabag. Assessment of epicardial adipose tissue thickness and total calcium score in sarcoidosis patients. Turk Kardiyol Dern Ars. 2021; 49(1): 60-66
Corresponding Author: Emine Altuntaş, Türkiye
Manuscript Language: English