Angiotensin-Converting Enzyme Gene Polymorphism in Turkish Hypertensive Patients and its Association with Left Ventricular Hypertrophy [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2002; 30(12): 743-748

Angiotensin-Converting Enzyme Gene Polymorphism in Turkish Hypertensive Patients and its Association with Left Ventricular Hypertrophy

Hakan TEZCAN1, Serhan TUĞLULAR2, Candan ÇİFTÇİOĞLU2, Ali Serdar FAK1, Turgay IŞBİR3, Çetin ÖZENER2, Emel AKOĞLU2, Ahmet OKTAY1
1
2
3

The association between ACE gene polymorphism and left ventricular hypertrophy has been studied in different populations with conflicting results. The aim of this study was to investigate this issue in Turkish patients with essential hypertension. One- hundred and seventeen hypertensive patients and 75 healthy controls were studied. Left ventricular mass indexes were examined by echocardiography and PCR technique was used to analyze ACE gene polymorphism. The distribution for DD, ID and II genotypes was not significantly different between patients (42%, 49% and 9%) versus controls (35%,53% and 12%). Allelic frequencies were also similar in both groups (66 vs 62% for D, and 34 vs 38% for I allele in patients vs controls respectively). The prevalence of LVH was 35% in hypertensive group and the genotypic distribution (DD, ID and II) was not significantly different between patients with and without LVH (41%, 57%, 2% vs 42%, 45%, 13%, respectively). The LVMI was not different among the carriers of the three genotypes; mean values were 113±37 g/m2 in DD; 110±36 g/m2 in ID; and 96±11 g/m2 in II patients (p=0.5). In conclusion, ACE gene polymorphism showed no association with either the occurrence of left ventricular hypertrophy or left ventricular mass in Turkish hypertensive patients.


How to cite this article
Hakan TEZCAN, Serhan TUĞLULAR, Candan ÇİFTÇİOĞLU, Ali Serdar FAK, Turgay IŞBİR, Çetin ÖZENER, Emel AKOĞLU, Ahmet OKTAY. Angiotensin-Converting Enzyme Gene Polymorphism in Turkish Hypertensive Patients and its Association with Left Ventricular Hypertrophy. Turk Kardiyol Dern Ars. 2002; 30(12): 743-748
Manuscript Language: Turkish
© Copyright 2022 Archives of the Turkish Society of Cardiology
LookUs & Online Makale