Archives of the
Turkish Society of Cardiology
Original Article - Pediatric Cardiology

Transcatheter closure of secundum atrial septal defects using the Amplatzer septal occluder in adult patients: our first clinical experiences


Erciyes Üniversitesi Tıp Fakültesi, Kardiyoloji Bilim Dalı, Kayseri


Erciyes Üniversitesi Tıp Fakültesi, Pediatrik Kardiyoloji Bilim Dali, Kayseri

Archives of the Turkish Society of Cardiology 2008; 36: 287-293
Read: 429 Downloads: 142 Published: 01 July 2021

Objectives: We evaluated short-term results of transcatheter closure of secundum atrial septal defects (ASD) with the Amplatzer septal occluder (ASO) in adults. Study design: The study included 12 patients (6 males, 6 females; mean age 31±9 years; range 17 to 54 years) who underwent transcatheter ASD closure with the ASO device. Prior to the procedure, the mean pulmonary to systemic flow ratio was 1.9±0.3 (range 1.5 to 2.6). The mean ASD diameter measured by transesophageal echocardiography was 13.9±2.8 mm, the mean stretched diameter of ASD measured by balloon sizing was 15.8±3.4 mm, and the mean ASO device diameter was 17.3±4.7 mm. The patients were evaluated before and six months after the procedure by echocardiography, electrocardiography, and the New York Heart Association (NYHA) functional classification. Results: Transcatheter ASD closure was successfully performed in 11 patients (91.7%). The mean procedure time was 72 minutes. There was no residual shunt at six months after closure. No serious complications occurred during the procedure and within a mean follow-up of 11.6±2.3 months. Echocardiographic examination at six months showed significant decreases in right ventricular end-diastolic diameter (VEDD) (p=0.007), right/left VEDD ratio (0.003), systolic pulmonary artery pressure (p=0.017), and significant increases in left ventricular ejection fraction (p=0.014) and left VEDD (p=0.005). There were significant decreases in maximum (p=0.003) and minimum (p=0.006) P-wave durations, and P-wave dispersion (p=0.028). The NYHA functional capacity improved significantly from 1.8±0.8 to 1.3±0.5 (p=0.014). Conclusion: Transcatheter closure of secundum ASD with the ASO device is a safe and effective method in adult patients, resulting in significant improvement in clinical symptoms and cardiac dimensions.

ISSN 1016-5169 EISSN 1308-4488