Archives of the
Turkish Society of Cardiology
Original Article

The Relationships Between Chocolate Consumption and Endothelial Dysfunction in Patients with Heart Failure


Department of Cardiology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey


Department of Biochemistry, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey

Archives of the Turkish Society of Cardiology 2022; 50: 334-339
DOI: 10.5543/tkda.2022.21249
Read: 149 Downloads: 35 Published: 01 July 2022

Objective: Dietary recommendations, in addition to medications, have recently become important in the treatment of heart failure. Our study aimed to show the positive effects of both milk chocolate and dark chocolate on heart failure through endothelial functions.

Methods: Twenty patients with heart failure and reduced ejection fraction were included in the study. In this randomized, crossover study, some of the patients consumed milk chocolate and some consumed dark chocolate. We recorded the patients' 6-minute walking tests, flow- mediated dilatation values, plasma catechin, epicatechin, and N-terminal pro-brain natri- uretic peptide values before and after chocolate consumption. After 2 weeks, their chocolate consumption was changed. The same parameters were measured again.

Results: A significant decrease was observed in N-terminal pro-brain natriuretic peptide values after consumption of both milk chocolate (356 ± 54.2 and 310 ± 72.1 pg/mL; P = .007) and dark chocolate (341 ± 57 and 301 ± 60.1 pg/mL;P=.028). Flow-mediated dilation values increased after dark chocolate consumption (8.9 ± 3% and 14 ± 4.5%; P = .019).

Conclusion: Chocolate consumption acutely decreases N-terminal pro-brain natriuretic pep- tide values in heart failure. Dark chocolate consumption also seems to improve endothelial functions by increasing flow-mediated dilation values.

Cite this article as: Dural İE, Onrat E, Çelik S, et al. The relationships between chocolate consumption and endothelial dysfunction in patients with heart failure. Turk Kardiyol Dern Ars. 2022;50(5):334-339.

ISSN 1016-5169 EISSN 1308-4488