Archives of the
Turkish Society of Cardiology
Original Article - Coronary artery disease

Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio

1.

Kocaeli Derince Eğitim Ve Araştırma Hastanesi, Kardiyoloji Kliniği

2.

Kartal Kosuyolu Kalp Eğitim Ve Araştırma Hastanesi, Kardiyoloji Kliniği

3.

Fatih Medical Park Hastanesi, Kardiyoloji Kliniği

4.

Medipol Üniversite Hastanesi, Kardiyoloji Kliniği

Archives of the Turkish Society of Cardiology 2013; 41: 617-624
DOI: 10.5543/tkda.2013.68625
Read: 305 Downloads: 83 Published: 01 July 2021

Objectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20±3 months after acute MI.

Study design: 58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated.

Results: The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were significantly correlated with left ventricular ejection fraction (LVEF) (ρ=0.34, p=0.009), end diastolic volume index (EDVi) (ρ=-0.39, p=0.002) and end systolic volume index (ESVi) (ρ=-0.40, p=0.002).

Conclusion: Plasma MMP-8 levels were found to still be high in post-MI patients 20±3 months after the index event. The levels were significantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function.

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TURKISH
ISSN 1016-5169 EISSN 1308-4488