Archives of the
Turkish Society of Cardiology
Original Article - General

Increased serum asymmetric dimethylarginine level is an independent predictor of contrast-induced nephropathy

1.

Harran Üniversitesi Tıp Fakültesi, Kardiyoloji Ana Bilim Dalı, Şanlıurfa, Türkiye

2.

Kayseri Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü, Kayseri, Türkiye

3.

Erciyes Üniversitesi Tıp Fakültesi, Kardiyoloji Ana Bilim Dalı, Kayseri, Türkiye

4.

Erciyes Üniversitesi Tıp Fakültesi, Biyokimya Ana Bilim Dalı, Kayseri, Türkiye

Archives of the Turkish Society of Cardiology 2013; 41: 581-588
DOI: 10.5543/tkda.2013.88403
Read: 453 Downloads: 145 Published: 01 July 2021

Objectives: The aim of our study was to evaluate whether serum asymmetric dimethylarginine (ADMA) level is an independent predictor of contrast-induced nephropathy (CIN).

Study design: The study involved 90 consecutive patients with stable angina pectoris who underwent coronary angiography and ventriculography. Baseline serum creatinine (SCr) levels ranged between ≥1.2 and <2 mg/dl. All patients were hydrated with intravenous isotonic saline at a rate of 1 ml/kg per hour for 6 hours before and 12 hours after the procedure. The primary end point was the occurrence of CIN. The secondary end point was the change in SCr levels at day 2 after the contrast exposure. Serum ADMA was determined by the ELISA method.

Results: The CIN rate was 11.1%. We detected a statistically significantly higher serum ADMA level in the CIN(+) group compared to that of the CIN(–) group [210.6 ng/ml (115.6-217.2) vs. 91.5 ng/ml (65.2-122.1), p=0.01]. Mehran risk score and diabetes mellitus (DM) ratio were higher in the CIN(+) group compared to those values in the CIN(-) group [8 (5.75-10) vs. 5 (5-7), p=0.01 and 70% vs. 26.3%, p=0.01, respectively]. Serum ADMA level, Mehran risk score and DM were independent predictors of CIN (odds ratio (OR) 1.030, 95% confidence interval (CI) 1.011-1.050, p=0.002; OR 1.565, 95% CI 1.102- 2.223, p=0.012; OR 9.422, 95% CI 1.441-61.598, p=0.019, respectively). A serum ADMA level of >124.7 ng/ml had 80% sensitivity and 76% specificity in predicting the development of CIN. In addition, we found a positive correlation between SCr change and serum ADMA level (p=0.001, r=0.35).

Conclusion: Our study demonstrates that increased serum ADMA level is an independent predictor of CIN.

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ISSN 1016-5169 EISSN 1308-4488