Archives of the
Turkish Society of Cardiology
Original Article

Does MicroRNA Profile Differ in Early Onset Coronary Artery Disease?

1.

Department of Cardiology, Faculty of Medicine, Katip Çelebi University, İzmir, Turkey

2.

Department of Medical Biology, Faculty of Medicine, Ege University, İzmir, Turkey

3.

Department of Biochemistry, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey

4.

Department of Cardiology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey

5.

Department of Cardiology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey

Archives of the Turkish Society of Cardiology 2022; 50: 407-414
DOI: 10.5543/tkda.2022.22408
Read: 620 Downloads: 134 Published: 01 September 2022

Objective: MicroRNAs have been explored as potential biomarkers for many pathological processes including coronary artery disease. In this study, we aimed to compare the circulating levels of selected atherosclerosis-associated miRNAs in patients with a history of early-onset coronary artery disease with that of age- and sex-matched healthy controls and older patients with late-onset coronary artery disease.

Methods: Study population consisted of 30 patients with early onset coronary artery disease, 31 age- and sex-matched healthy controls, and 30 patients with late-onset coronary artery disease. Plasma levels of 13 microRNAs (endothelial cell-related miR-126, -92a/b; vascular smooth muscle cell-related miR-145; inflammation-related miR-16, -21, -125b, -146a/b, -147b, -150, -155; lipometabolism-related miR-27b, -122, -370) were evaluated by using real-time polymerase chain reaction.

Results: In patients with early onset coronary artery disease, plasma expressions of the lipometabolism-related miR-27b, miR-122; inflammation-related miR-125b, miR-146a/b, miR-147b, miR-150, miR-155; and VSMC-related miR-145 were significantly downregulated and endothelial cell-related miR-126 was significantly upregulated compared to age- and sexmatched healthy controls. Circulating microRNA profile of patients with early onset coronary artery disease was also different from that of older patients with late-onset coronary artery disease. Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease.

Conclusion: MicroRNAs are promising biomarkers for early onset coronary artery disease.

Cite this article as: Kahya Eren N, Karaca E, Şirin FB, et al. Does MicroRNA profile differ in early onset coronary artery disease? Turk Kardiyol Dern Ars. 2022;50(6):407-414.

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