Archives of the Turkish Society of Cardiology
Relationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2013; 41(5): 379-385 | DOI: 10.5543/tkda.2013.97253

Relationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery disease

İbrahim Halil Tanboğa1, Mehmet Mustafa Can2, Alper Özkan3, Hacer Ceren Tokgöz2, Taylan Akgün2, Fatih Koca2, Mustafa Kurt4, Cihangir Kaymaz2
1Department Of Cardiology, Ataturk University Medical School, Erzurum, Turkey
2Department Of Cardiology, Kartal Koşuyolu Heart Education And Research, Istanbul, Turkey
3Department Of Cardiology, Cleveland Clinic, Heart And Vascular Institue, Cleveland, Ohio, Usa
4Department Of Cardiology, Mustafa Kemal University Medical School, Hatay, Turkey


OBJECTIVES
It has been proposed that human platelet antigen- 1 (HPA-1) gene polymorphism is associated with coronary artery disease (CAD) and affects platelet function. We aimed to investigate the distribution of HPA gene polymorphism between angiographic CAD and a control group and the relation between HPA gene polymorphism and platelet aggregation.

STUDY DESIGN
The study population consisted of 94 patients with angiographic CAD and 115 patients without angiographic CAD. Platelet aggregation was measured with impedance aggregometry on the fifth day of percutaneous coronary intervention (PCI). Platelet aggregation >480 AU*min was defined as the clopidogrel resistance group. Blood samples were obtained from all participants at discharge for investigating HPA- 1 gene polymorphism.

RESULTS
There was no significant difference in the distribution of HPA-1 gene polymorphism between the control and CAD groups (78.7% vs. 78.1% for A allele and 21.3% vs. 21.9% for B allele, p=NS). The analysis between groups with and without clopidogrel resistance revealed no significant difference in the distribution of HPA-1A and HPA-1B alleles between the groups (A allele 78.7% vs. 78.9% and B allele 21.3% vs. 21.1%, p=NS). In the CAD group, there were no significant differences in platelet aggregation between HPA-1A and HPA- 1B alleles (294±240 vs. 259±261 AU*min, p=NS).

CONCLUSION
The distribution of HPA-1 gene polymorphism was not different in CAD patients compared to the control group. HPA-1 gene polymorphism was not associated with platelet aggregation or clopidogrel resistance assessed by impedance aggregometry in the CAD group.

Keywords: Angioplasty, balloon, coronary/methods, dose-response relationship, drug; drug resistance; human platelet antigen-1; clopidogrel; percutaneous coronary intervention; polymorphism, genetic; platelet aggregation/drug effects/genetics.

How to cite this article
İbrahim Halil Tanboğa, Mehmet Mustafa Can, Alper Özkan, Hacer Ceren Tokgöz, Taylan Akgün, Fatih Koca, Mustafa Kurt, Cihangir Kaymaz. Relationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery disease. Turk Kardiyol Dern Ars. 2013; 41(5): 379-385

Corresponding Author: İbrahim Halil Tanboğa, Türkiye
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