ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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“Not-so-identical” twins with trisomy 21 and perimembranous ventricular septal defects [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(4): 346-349 | DOI: 10.5543/tkda.2016.96605

“Not-so-identical” twins with trisomy 21 and perimembranous ventricular septal defects

Sarosh P Batlivala1, Kendra S Courtney1, Makram R Ebeid2, Aimee S Parnell2
1University Of Mississippi Medical Center, School Of Medicine, Jackson, MS, USA
2Blair E. Batson Hospital For Children, Division Of Pediatric Cardiology, Jackson, MS USA

Summary– While trisomy 21 is a common genetic disorder in singletons, the incidence among identical twins is very rare, occurring in approximately 1–2 per 1000 twin gestations. Trisomy 21 is associated with high incidence of congenital heart defects, and commonly occurs with ventricular septal defects (VSDs). Physiologic burden of VSDs depends on prevalence of anatomic and other circulatory factors. A case of identical twins with trisomy 21 and large VSDs is described in the present report. Though genetically identical, phenotypes varied significantly. One twin was managed medically, while the other developed more significant heart failure, requiring operative repair.

Keywords: Congenital heart disease, trisomy 21, epidemiology, physiology.

How to cite this article
Sarosh P Batlivala, Kendra S Courtney, Makram R Ebeid, Aimee S Parnell. “Not-so-identical” twins with trisomy 21 and perimembranous ventricular septal defects. Turk Kardiyol Dern Ars. 2016; 44(4): 346-349

Corresponding Author: Sarosh P Batlivala, United States
Manuscript Language: English


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